Changes in Eicosanoid and Tumour Necrosis Factor-α Production by Rat Peritoneal Macrophages During Carrageenin-Induced Peritonitis

Changes and correlations in cytokine and eicosanoid production by blood monocytes, non-purified and purified peritoneal cells during a carrageenin-induced peritonitis were investigated for a period of ten days. The cells were isolated and stimulated in vitro. Cytokine and eicosanoid production of the non-purified fraction increased steadily during peritonitis. During the whole episode of peritonitis the production capacity of granulocytes was very low and hardly any effect on the production capacity of macrophages (Mϕ) was observed. Cytokine and eicosanoid production of the non-purified fraction was mainly due to the presence of Mϕ. The production capacity of the peripheral blood monocytes was not similar to that of the peritoneal Mϕ.

• Publication year

  1994

• Venue

  Mediators of Inflammation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/S0962935194000463PMID 18475577PMCID 2365571
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A comparison between two methods for measuring tumor necrosis factor in biological fluids

  2005cited by this paper
• Cytotoxic effector cells of the immune system

  2004cited by this paper
• Cell adhesion in the immune system.

  1993cited by this paper
• Quantitation and kinetics of blood monocyte migration to acute inflammatory reactions, and IL-1 alpha, tumor necrosis factor-alpha, and IFN-gamma.

  1993cited by this paper
• Activity of human peritoneal macrophages against a human tumor: role of tumor necrosis factor-alpha, PGE2 and nitrite, in vitro studies.

  1993cited by this paper
• Inflammatory cytokines.

  1992cited by this paper
• The versatility of macrophages

  1992cited by this paper
• Tumor necrosis factor production by human granulocytes.

  1991cited by this paper
• Arachidonic acid metabolism in normal human alveolar macrophages: stimulus specificity for mediator release and phospholipid metabolism, and pharmacologic modulation in vitro and in vivo.

  1990cited by this paper
• Inducible production of interleukin-6 by human polymorphonuclear neutrophils: role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha.

  1990cited by this paper
• Interactions between inflammatory mediators in expression of antitumor cytostatic activity of macrophages.

  1990cited by this paper
• Adhesion receptors of the immune system

  1990cited by this paper
• Monocyte and neutrophil chemotaxis in psoriasis. Clinical and experimental studies.

  1989cited by this paper
• The cytokine network.

  1989cited by this paper
• Comparison of the production of eicosanoids by human and rat peritoneal macrophages and rat Kupffer cells.

  1988cited by this paper
• Granulocyte/macrophage colony-stimulating factor induces interleukin 1 production by human polymorphonuclear neutrophils.

  1988cited by this paper
• Molecular mechanisms of signal transduction in macrophages.

  1987cited by this paper
• Secretory products of macrophages.

  1987cited by this paper
• In vitro studies of human monocyte migration across endothelium in response to leukotriene B4 and f-Met-Leu-Phe.

  1987cited by this paper
• The basis for the immunoregulatory role of macrophages and other accessory cells.

  1987cited by this paper
• Current concepts: immunology. Neutrophils in human diseases.

  1987cited by this paper
• Monocyte and neutrophil chemotaxis in psoriasis. Relation to the clinical status and the type of psoriasis.

  1986cited by this paper
• Leukotrienes: their formation and role as inflammatory mediators.

  1985cited by this paper
• Macrophage heterogeneity.

  1984cited by this paper
• Carrageenan-induced suppression of T-lymphocyte proliferation in the rat: abrogation of suppressor factor production by the prostaglandin synthesis inhibitors, indomethacin and ETYA.

  1984cited by this paper
• Prostaglandins and thromboxanes.

  1978cited by this paper
• Prostaglandins and Thromboxanes

  1977cited by this paper
• THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

  1968cited by this paper
• The mononuclear response to intrapleural injection in the rat.

  1966cited by this paper

• No citing papers are available for this paper.