The hamster cheek pouch as a model of oral cancer for boron neutron capture therapy studies: selective delivery of boron by boronophenylalanine.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Cancer Research

• Publication date

  2001-12-15

• Fields of study

  Medicine, Physics

• Identifiers
  PMID 11751398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• Rat brain tumor models in experimental neuro-oncology:The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 Gliomas

  2004cited by this paper
• [In search of new treatment methods for head-neck carcinoma].

  1999cited by this paper
• Auf der Suche nach neuen Behandlungsstrategien beim Kopf-Hals-Karzinom *

  1999cited by this paper
• Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies

  1999cited by this paper
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  1999cited by this paper
• Effect of Dose and Infusion Time on the Delivery of p-boronophenylalanine for Neutron Capture Therapy

  1999cited by this paper
• The effects of boron neutron capture irradiation on oral mucosa: evaluation using a rat tongue model.

  1999cited by this paper
• The radiation biology of boron neutron capture therapy.

  1999influential reference
• Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy.

  1998cited by this paper
• Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: boron concentration correlates with tumor cellularity.

  1998influential reference
• Multiple Primary Malignant Tumors in Patients With Head and Neck Cancer

  1998cited by this paper
• Molecular epidemiology and retinoid chemoprevention of head and neck cancer.

  1997cited by this paper
• Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption.

  1997cited by this paper
• Boron neutron capture therapy: Clinical brain tumor studies

  1997cited by this paper
• Boron neutron capture irradiation of the rat spinal cord: histopathological evidence of a vascular-mediated pathogenesis.

  1996cited by this paper
• AgNOR mark epithelial foci in malignant transformation in hamster cheek pouch carcinogenesis.

  1996cited by this paper
• Radiobiological evidence suggesting heterogeneous microdistribution of boron compounds in tumors: its relation to quiescent cell population and tumor cure in neutron capture therapy.

  1996cited by this paper
• Evolution of the Radiation Therapy Oncology Group clinical trials for head and neck cancer.

  1996cited by this paper
• Brain Tolerance in Dogs to Boron Neutron Capture Therapy with Borocaptate Sodium (BSH) or Boronophenylalanine (BPA)

  1996cited by this paper
• Monitoring of blood-10B concentration for boron neutron capture therapy using prompt gamma-ray analysis.

  1995cited by this paper
• A nude rat model for neutron capture therapy of human intracerebral melanoma.

  1994cited by this paper
• Boron neutron capture therapy: a guide to the understanding of the pathogenesis of late radiation damage to the rat spinal cord.

  1994cited by this paper
• Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy.

  1994cited by this paper
• Boron neutron capture therapy of malignant melanoma using 10B-paraboronophenylalanine with special reference to evaluation of radiation dose and damage to the normal skin.

  1994cited by this paper
• Neutron capture therapy of the 9L rat gliosarcoma using the p-boronophenylalanine-fructose complex.

  1994cited by this paper
• Nucleolar organizer regions in lining epithelium adjacent to squamous cell carcinoma of human oral mucosa

  1994cited by this paper
• Clinical phase-I study of Na2B12H11SH (BSH) in patients with malignant glioma as precondition for boron neutron capture therapy (BNCT).

  1994cited by this paper
• Bioavailability of Intravenous Formulations of P-Boronophenylalanine in Dog and Rat

  1993cited by this paper
• Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent.

  1993cited by this paper
• Advances in Neutron Capture Therapy

  1993cited by this paper
• Control of intracerebral gliosarcomas in rats by boron neutron capture therapy with p-boronophenylalanine.

  1992cited by this paper
• Multiple primary cancers in Hong Kong Chinese patients with squamous cell cancer of the head or neck

  1992cited by this paper
• Boron neutron capture therapy of a murine melanoma with p-boronophenylalanine: dose-response analysis using a morbidity index.

  1991cited by this paper
• Creatine kinase isoenzymes activity in serum and buccal pouch tissue of hamsters during DMBA-induced squamous cell carcinogenesis.

  1991cited by this paper
• Selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma.

  1990cited by this paper
• Changes in keratin expression during 7,12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis.

  1990cited by this paper
• Lectin binding patterns in squamous epithelium in experimentally induced hamster buccal pouch carcinoma.

  1989cited by this paper
• Improvement of solubility of p-boronophenylalanine by complex formation with monosaccharides.

  1989cited by this paper
• Time- and dose-related changes in the white matter of the rat brain after single doses of X rays.

  1988cited by this paper
• Low level X-radiation effects on carcinogenesis by 7,12-dimethylbenz(a)anthracene in Syrian hamster cheek pouch epithelium: acute vs fractionated radiation dose studies.

  1987cited by this paper
• A quatitative histochemical technique for the study of vascularization in tissue sections using horseradish peroxidase

  1984cited by this paper
• The relative biological effectiveness in V79 Chinese hamster cells of the neutron capture reactions in boron and nitrogen.

  1984cited by this paper
• Anatomical and functional vascular changes in hamster cheek pouch during carcinogenesis induced by 7, 12-dimethylbenz(a)anthracene.

  1983cited by this paper
• Chemotherapy in head and neck cancer.

  1983cited by this paper
• Immunoenhancing agents and experimental leukoplakia and carcinoma of the hamster buccal pouch.

  1979cited by this paper
• Tobacco and alcohol consumption in relation to the development of multiple primary cancers

  1977cited by this paper
• Multiple primary cancers of the lung, esophagus, and other sites

  1977cited by this paper
• Early and late changes in the functional vascularity of the hamster cheek pouch after local x-irradiation.

  1975cited by this paper
• Smoking characteristics of patients with oral carcinoma and the risk for second oral primary carcinoma.

  1972cited by this paper
• A variance in hamster pouch carcinogenesis in tissue irradiated with 200 KVP x-rays and cobalt-60 x-rays.

  1970cited by this paper
• HISTOCHEMISTRY OF EXPERIMENTALLY INDUCED LEUKOPLAKIA AND CARCINOMA OF THE HAMSTER BUCCAL POUCH.

  1964cited by this paper
• Factors Influencing Experimental Carcinogenesis in the Hamster Cheek Pouch

  1961cited by this paper
• Experimental Carcinogenesis in the Cheek Pouch of the Syrian Hamster

  1954cited by this paper
• “Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

  1953cited by this paper
• Detection of Nuclear Disintegration in a Photographic Emulsion

  1935cited by this paper

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  2025cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2019cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model

  2014cites this paper
• Boron neutron capture therapy for oral precancer: proof of principle in an experimental animal model.

  2013cites this paper
• Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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• Effects of Some Boron Compounds on Peripheral Human Blood

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  2007cites this paper
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  2007cites this paper
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  2006cites this paper
• Boron-Containing Bioactive Molecules: An Approach to Boron Neutron Capture Therapy

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• Effects of boron neutron capture therapy on human oral squamous cell carcinoma in a nude mouse model

  2006influential citation
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