Thiol/disulfide homeostasis in patients with chronic hepatitis B

Amac: Bu calismanin amaci, oksidatif stres belirteci olarak kullanilan tiyol / disulfit dengesi ile kronik hepatit B (KHB) arasindaki iliskiyi degerlendirmektir. Gerec ve Yontem: Bu calisma Mayis 2016 - Temmuz 2016 tarihleri ​​arasinda Erzurum Bolge Egitim ve Arastirma Hastanesi Enfeksiyon Hastaliklari Polikliniginde yapildi. Calismaya KHB’li 63 hasta ve bilinen herhangi bir hastaligi olmayan 60 saglikli gonullu dahil edildi. Dinamik tiyol /disulfit dengesini olcmek icin Erel ve Neselioglu tarafindan gelistirilen yeni otomatik analiz yontemini kullanildi. Dogal tiyolden (SH) sonra, toplam tiyol (toplam SH) ve disulfit (SS) seviyeleri belirlendi; SS/SH, SS/toplam SH ve SH/toplam SH gibi olculer hesaplandi. Bulgular: KHB grubunda, SH seviyelerinin (P=0,041), toplam SH seviyelerinin (P = 0,043) kontrol grubundan dusuk oldugunu tespit edildi. Anti-HBc toplam IgG ile toplam SH, SH, SH/toplam SH arasinda negatif korelasyon vardi, Anti-HBc toplam IgG ile SS/SH, SS/toplam SH orani arasinda pozitif korelasyon vardi. BMX indeksi ile toplam SH, SH, SH/toplam SH arasinda negatif, SS/total SH, SS/SH arasinda pozitif korelasyon vardi. Toplam protein, albumin ve toplam SH, SH arasinda pozitif korelasyon bulundu. Sonuc: Calismamizda KHB hastalarinda antioksidan olarak tiyol duzeyleri dusuk bulundu. Hepatit B’de tiyol duzeyinin yeni bir belirtec oldugu tekrar vurgulandi. Gelecekte yapilacak daha genis calismalarla KHB’de tiyol duzeyleri hem hastaligin seyrinin yavaslatilmasi hemde yeni tedavi gelistirme cabalarina isik tutacagi dusunulmektedir.

• Publication year

  2020

• Venue

  Ortadoğu Tıp Dergisi

• Publication date

  2020-06-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.21601/ORTADOGUTIPDERGISI.752362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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