Aspiration in intubated premature infants.

A recent study has shown a 77% incidence of tracheal aspiration in children (mean age 13.4 months) who are intubated with uncuffed endotracheal tubes. To determine both the incidence of such aspiration among premature infants and whether continuous positive airway pressure (CPAP) has any preventive effect, 20 tracheally intubated neonates were evaluated for the presence of tracheal aspiration of orally placed Evan's blue dye. The overall incidence of aspiration was 80%. Eighteen of these infants were tested during both 4 cm and 6 cm H2O continuous positive airway pressure, and the incidences of aspiration were 72% and 50%, respectively, which is not a statistically significant difference (P less than .17). Ten of these 18 patients were also studied when 2 cm H2O was applied and 60% aspirated. Among all infants who aspirated, compared with those who did not, there was a small but statistically significant decrease in transcutaneous PO2 (P less than .05) as well as an increase in respiratory (P less than .001) and pulse (P less than .01) rates. It is concluded that tracheally intubated neonates frequently aspirate and that clinically useful levels of continuous positive airway pressure are not likely to prevent aspiration.

• Publication year

  1985

• Venue

  Pediatrics

• Publication date

  1985-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1542/peds.75.1.85PMID 3880882
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Among infants who aspirated, transcutaneous PO2 was slightly lower while respiratory rate and pulse rate were higher than in infants who did not aspirate.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• Clinically useful levels of continuous positive airway pressure are unlikely to prevent tracheal aspiration in these intubated neonates.

  Confidence 0.93

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• Aspiration rates under 4 cm H2O and 6 cm H2O continuous positive airway pressure were 72% and 50%, a difference that was not statistically significant.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• Tracheally intubated neonates frequently exhibited tracheal aspiration in the dye test, with an overall incidence of 80% among the 20 infants evaluated.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review

• continuous positive airway pressure

  intervention

  A respiratory support modality that delivers constant positive pressure to the airway at set levels.

  Aliases: CPAP

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• evan's blue dye

  marker, reagent

  A blue dye placed orally to detect whether swallowed material reached the trachea.

  Aliases: Evans blue dye

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• pulse rate

  measurement

  The number of pulses per unit time, used here as a physiologic measure.

  Aliases: heart rate, pulse

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• respiratory rate

  measurement

  The number of breaths taken per unit time, used here as a physiologic measure.

  Aliases: breathing rate, respiratory frequency

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• tracheal aspiration

  outcome, clinical event

  Entry of oral material into the trachea that was assessed in this study using dye.

  Aliases: aspiration, airway aspiration

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• tracheally intubated neonates

  population

  Newborn infants in whom an endotracheal tube had been placed for airway management.

  Aliases: intubated neonates, tracheally intubated infants

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• transcutaneous po2

  measurement

  A noninvasive measurement of oxygen tension taken through the skin.

  Aliases: TcPO2, transcutaneous oxygen tension

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review

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