Interplay of the Circadian Clock and Endothelin System.

The peptide hormone endothelin-1 and its receptors are linked to several disease states. Pharmacological inhibition of this pathway has proven beneficial in pulmonary hypertension, yet its potential in other disease states remains to be realized. This review considers an often understudied aspect of endothelin biology, circadian rhythm regulation and how understanding the intersection between endothelin signaling and the circadian clock may be leveraged to realize the potential of endothelin-based therapeutics.

• Publication year

  2021

• Venue

  Physiology

• Publication date

  2021-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/physiol.00021.2020PMID 33325818PMCID PMC7938768
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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