Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  International Journal of Radiation Oncology, Biology, Physics

• Publication date

  2003-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0360-3016(02)04503-0PMID 12738312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999influential reference
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  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1999influential reference
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1992cited by this paper

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