Mechanism of activation of human ras genes cloned from a gastric adenocarcinoma and a pancreatic carcinoma cell line.

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Cancer Research

• Publication date

  1986-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 3731120
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

  1985cited by this paper
• Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon.

  1985cited by this paper
• Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells

  1985cited by this paper
• Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

  1985cited by this paper
• Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.

  1984cited by this paper
• An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells.

  1984cited by this paper
• c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene.

  1984cited by this paper
• G proteins and dual control of adenylate cyclase.

  1984cited by this paper
• Biological properties of human c-Ha-ras1 genes mutated at codon 12

  1984cited by this paper
• Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

  1984cited by this paper
• Comparative biochemical properties of normal and activated human ras p21 protein

  1984cited by this paper
• Characterization of human transforming genes from chemically transformed, teratocarcinoma, and pancreatic carcinoma cell lines.

  1984cited by this paper
• New human transforming genes detected by a tumorigenicity assay

  1984influential reference
• Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.

  1984cited by this paper
• Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

  1984cited by this paper
• Mechanism of activation of an N‐ras gene in the human fibrosarcoma cell line HT1080.

  1984cited by this paper
• Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

  1983cited by this paper
• Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

  1983cited by this paper
• Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

  1983cited by this paper
• Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

  1983cited by this paper
• Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

  1983cited by this paper
• Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

  1983cited by this paper
• Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

  1983cited by this paper
• Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

  1983cited by this paper
• Identification by transfection of transforming sequences in DNA of human T-cell leukemias.

  1983cited by this paper
• Three human transforming genes are related to the viral ras oncogenes.

  1983cited by this paper
• Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.

  1983cited by this paper
• Structure and activation of the human N-ras gene.

  1983cited by this paper
• Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product.

  1983cited by this paper
• New method for detecting cellular transforming genes.

  1982cited by this paper
• Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

  1982cited by this paper
• Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

  1982cited by this paper
• Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

  1982cited by this paper
• T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

  1982cited by this paper
• Mechanism of activation of a human oncogene

  1982cited by this paper
• Isolation of a transforming sequence from a human bladder carcinoma cell line.

  1982cited by this paper
• Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

  1982cited by this paper
• Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

  1981cited by this paper
• The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

  1981cited by this paper
• Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency.

  1980cited by this paper
• Ubiquitous, interspersed repeated sequences in mammalian genomes.

  1980cited by this paper
• Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses.

  1979cited by this paper
• Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus.

  1979cited by this paper
• A new method for sequencing DNA.

  1977cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper

• BRAF, NRAS, HRAS genes profile in human melanoma cell lines

  2009cites this paper
• Growth factors and oncogenes in human gastrointestinal carcinomas

  2005cites this paper
• substance P (6 -11)-induced growth inhibition

  2003cites this paper
• Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6–11)-induced growth inhibition

  2003influential citation
• Cholecystokinin receptors in human pancreatic cancer cell lines.

  1998cites this paper
• P21 protein expression and ras-oncogene mutations in gastric carcinoma: correlation with clinical data.

  1998cites this paper
• Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action

  1996cites this paper
• Lovastatin Inhibits Pancreatic Cancer Growth Regardless of RAS Mutation

  1994cites this paper
• Activation of oncogene c-Ha-ras in gastric cancer of Chinese patients.

  1994cites this paper
• Characterization of four new gastric cancer cell lines

  1993cites this paper
• c-Ki-ras癌遺伝子の点突然変異からみた同時性多発胃癌の研究

  1993cites this paper
• Evaluation of c-K-ras in pancreatic carcinomas from Ela-1, SV40E transgenic mice.

  1993cites this paper
• Inhibition of pancreatic adenocarcinoma cell growth by lovastatin.

  1992cites this paper
• Immunohistochemical analysis of ras oncogene p21 product in human gastric carcinomas and their adjacent mucosas.

  1992cites this paper
• Molecular pathology of gastric carcinoma: progress and prospects.

  1992cites this paper
• Correlation of mutations of oncogene C-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients.

  1991cites this paper
• Point Mutation of c‐Ki‐ras Oncogene in Gastric Adenoma and Adenocarcinoma with Tubular Differentiation

  1991cites this paper
• Biology of pancreatic cancer.

  1991cites this paper
• The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.

  1991cites this paper
• The Molecular Biology of Pancreatic Adenocarcinoma

  1991cites this paper
• Activation of c‐Ki‐ras not detectable in adenomas or adenocarcinomas arising in rat pancreas

  1990cites this paper
• Infrequent point mutations of ras oncogenes in gastric cancers.

  1990cites this paper
• Gastric dysplasia.

  1990cites this paper
• Mutational activation of the c-K-ras gene in human pancreatic carcinoma.

  1990cites this paper
• Heterogeneous protooncogene amplification correlates with tumor progression and presence of metastases in gastric cancer patients.

  1990cites this paper
• No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers.

  1990cites this paper
• An oncogenic chromosome 8-9 gene fusion isolated following transfection of human ovarian carcinoma cell line DNA.

  1990cites this paper
• Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.

  1990cites this paper
• Characteristics of cell lines established from human gastric carcinoma.

  1990cites this paper
• Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas.

  1989cites this paper
• The ras family of oncogenes.

  1989cites this paper
• Oncogenes in human solid tumors.

  1989cites this paper
• Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.

  1989cites this paper
• Oncogene Activation and Expression during Carcinogenesis in Liver and Pancreas

  1989cites this paper
• Characterization of a ras gene in rainbow trout

  1989cites this paper
• DNA ploidy・ras p21の発現からみたBorrmann4型胃癌の予後の検討

  1989cites this paper
• Expression of ras oncogene p21 protein in early gastric carcinoma and adjacent gastric epithelia

  1989cites this paper
• The ras gene family and human carcinogenesis.

  1988cites this paper
• Oncogenes and growth factors.

  1988cites this paper
• Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay.

  1988cites this paper
• Correlation between H-ras p21TLeu61 protein content and tumorigenicity of NIH3T3 cells.

  1988cites this paper
• [Activated oncogenes in human tumors].

  1987cites this paper
• Cellular oncogenes and human carcinogenesis.

  1987cites this paper