CTHRC1 is upregulated by promoter demethylation and transforming growth factor‐β1 and may be associated with metastasis in human gastric cancer

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cancer Science

• Publication date

  2012-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1349-7006.2012.02292.xPMID 22590977PMCID PMC7659176
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• TGF-beta1 interactome: metastasis and beyond.

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  2009cited by this paper
• Learning therapeutic lessons from metastasis suppressor proteins

  2009cited by this paper
• Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas.

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• Tissue level, activation and cellular localisation of TGF-β1 and association with survival in gastric cancer patients

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Transforming growth factor-beta signaling in cancer invasion and metastasis.

  2007cited by this paper
• Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis

  2007cited by this paper
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  2007cited by this paper
• Aberrant Expression of Collagen Triple Helix Repeat Containing 1 in Human Solid Cancers

  2006cited by this paper
• Epidemiology of gastric cancer.

  2006cited by this paper
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  2006cited by this paper
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  2004cited by this paper
• Alteration of DNA methylation in gastrointestinal carcinogenesis

  2001cited by this paper
• Gastric dysplasia: the Padova international classification.

  2000cited by this paper
• TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.

  1998cited by this paper
• Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994.

  1996cited by this paper

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