The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Proceedings of the Association of American Physicians

• Publication date

  1999-11-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/J.1525-1381.1999.99212.XPMID 10591082
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.

  2015cited by this paper
• Cyanine dye measurement of a light-induced transient membrane potential associated with the metarhodopsin II intermediate in rod-outer-segment membranes.

  2005cited by this paper
• Leukotriene A4 hydrolase and leukotriene C4 synthase activities in human chondrocytes: transcellular biosynthesis of Leukotrienes during granulocyte-chondrocyte interaction.

  1998cited by this paper
• Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

  1998cited by this paper
• Production of Leukotriene C4 in Different Human Tissues Is Attributable to Distinct Membrane Bound Biosynthetic Enzymes*

  1997cited by this paper
• Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

  1997cited by this paper
• Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.

  1997cited by this paper
• Profound overexpression of leukotriene C4 synthase in bronchial biopsies from aspirin-intolerant asthmatic patients.

  1997cited by this paper
• Role of cytosolic phospholipase A2 in allergic response and parturition

  1997cited by this paper
• Molecular cloning of the gene for mouse leukotriene-C4 synthase.

  1997cited by this paper
• Site-directed Mutagenesis of Human Leukotriene C4Synthase*

  1997cited by this paper
• Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.

  1996cited by this paper
• Treatment of systemic lupus erythematosus and antiphospholipid syndrome: from experimental models to patients' bedside.

  1996cited by this paper
• Molecular cloning, expression and characterization of mouse leukotriene C4 synthase.

  1996cited by this paper
• Cysteinyl Leukotriene D4 Induced Vascular Smooth Muscle Cell Proliferation: A Possible Role in Myointimal Hyperplasia

  1996cited by this paper
• Identification and Characterization of a Novel Human Microsomal Glutathione S-Transferase with Leukotriene C4 Synthase Activity and Significant Sequence Identity to 5-Lipoxygenase-activating Protein and Leukotriene C4 Synthase*

  1996cited by this paper
• Structural organization of the human microsomal glutathione S-transferase gene (GST12).

  1996cited by this paper
• Molecular Cloning of the Human Leukotriene C4 Synthase Gene and Assignment to Chromosome 5q35

  1996cited by this paper
• Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis.

  1995cited by this paper
• Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.

  1995cited by this paper
• Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate

  1995cited by this paper
• Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody.

  1995cited by this paper
• Interleukin-3 Regulates Development of the 5-Lipoxygenase/Leukotriene C4 Synthase Pathway in Mouse Mast Cells (*)

  1995cited by this paper
• Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.

  1995cited by this paper
• Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

  1995cited by this paper
• Receptor-mediated regulation of leukotriene C4 synthase activity in human platelets.

  1995cited by this paper
• Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

  1994cited by this paper
• Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells.

  1994cited by this paper
• Specific induction of LTC4 synthase by retinoic acid in rat basophilic leukemia-1 cells.

  1994cited by this paper
• Five identical intron positions in ancient duplicated genes of eubacterial origin

  1994cited by this paper
• Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.

  1994cited by this paper
• Molecular cloning and expression of human leukotriene-C4 synthase.

  1994cited by this paper
• Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.

  1994cited by this paper
• Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

  1993cited by this paper
• Leukotriene E4 and granulocytic infiltration into asthmatic airways.

  1993cited by this paper
• In vitro release of prostaglandins and leukotrienes from synovial tissue, cartilage, and bone in degenerative joint diseases.

  1993cited by this paper
• 5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase.

  1993cited by this paper
• On the nature of leukotriene C4 synthase in human platelets.

  1992cited by this paper
• Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells.

  1992cited by this paper
• Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors.

  1992cited by this paper
• Induction of leukotriene C4 synthase activity in differentiating human erythroleukemia cells.

  1992cited by this paper
• Purification of human leukotriene C4 synthase.

  1992cited by this paper
• Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.

  1992cited by this paper
• Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.

  1992cited by this paper
• A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP.

  1991cited by this paper
• Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP).

  1991cited by this paper
• Report of the committee on the genetic constitution of chromosome 5.

  1989cited by this paper
• Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5.

  1989cited by this paper
• The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils.

  1989cited by this paper
• IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity.

  1989cited by this paper
• Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3.

  1988cited by this paper
• Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4.

  1988cited by this paper
• Properties of highly purified leukotriene C4 synthase of guinea pig lung.

  1988cited by this paper
• Vascular smooth muscle cell leukotriene C4 synthesis: requirement for transcellular leukotriene A4 metabolism.

  1987cited by this paper
• Purification of a new acidic glutathione S-transferase, GST-Yn1Yn1, with a high leukotriene-C4 synthase activity from rat brain.

  1987cited by this paper
• cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

  1987cited by this paper
• Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links.

  1986cited by this paper
• Identification of a high affinity leukotriene C4-binding protein in rat liver cytosol as glutathione S-transferase.

  1986cited by this paper
• Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

  1986cited by this paper
• Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells.

  1985cited by this paper
• Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.

  1984cited by this paper
• Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators.

  1984cited by this paper
• Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4.

  1983cited by this paper
• Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.

  1983cited by this paper
• Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.

  1982cited by this paper
• Generation of leukotrienes by purified human lung mast cells.

  1982cited by this paper
• Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

  1981cited by this paper
• Leukotrienes are potent constrictors of human bronchi

  1980cited by this paper
• Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources.

  1980cited by this paper
• Leukotriene A4: enzymatic conversion to leukotriene C4.

  1980cited by this paper
• Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity.

  1980cited by this paper
• Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

  1979cited by this paper
• The Total-Eclipse of the Sun, September 21, 1922

  1923cited by this paper

• Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

  2025cites this paper
• Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption

  2022cites this paper
• Pharmacogenomics of Leukotriene Modifiers: A Systematic Review and Meta-Analysis

  2022cites this paper
• Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction

  2019cites this paper
• Unravelling adverse reactions to NSAIDs using systems biology.

  2015cites this paper
• Serum concentrations of eicosanoids and lipids in dogs naturally infected with Babesia canis.

  2014cites this paper
• 5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation

  2014cites this paper
• Mitogen-Activated Protein Phosphoinositide 3-Kinase Through a Phospholipase A2 in Human Eosinophils by Activation of Group IV Cytosolic

  2013cites this paper
• Impact of IL-33 on PGD2 Generation by Activated Human Cord Blood-Derived Mast Cell: Lack of Effect on Tryptase Release

  2012cites this paper
• Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.

  2011cites this paper
• Batatasin I, a naturally occurring phenanthrene derivative, isolated from tuberous roots of Dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast cells.

  2011cites this paper
• Leukotriene receptors.

  2011cites this paper
• Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells.

  2011cites this paper
• Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation.

  2009cites this paper
• Chapter 6 – Prostaglandins and Other Lipid Mediators in Reproductive Medicine

  2009cites this paper
• An experimental study of mediators in allergic bronchoconstriction with focus on eicosanoids

  2008cites this paper
• Asthma: a syndrome composed of heterogeneous diseases.

  2008cites this paper
• The Role of Bone in the Development of Osteoarthritis

  2007cites this paper
• Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats

  2007cites this paper
• The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein

  2006cites this paper
• LTB4 Can Directly Stimulate Human Osteoclast Formation from PBMC Independent of RANKL

  2005cites this paper
• Kinase-Independent Pathway Mitogen-Activated Protein Phosphoinositide 3-Kinase Through a in Human Eosinophils by 2 Phospholipase A Activation of Group IV Cytosolic

  2003cites this paper
• Activation of Group IV Cytosolic Phospholipase A2 in Human Eosinophils by Phosphoinositide 3-Kinase Through a Mitogen-Activated Protein Kinase-Independent Pathway 1

  2003cites this paper
• Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling

  2003cites this paper
• Role of eicosanoids in structural degradation in osteoarthritis

  2003cites this paper
• Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.

  2002cites this paper
• Characterization of Mouse Cysteinyl Leukotriene Receptors mCysLT1 and mCysLT2

  2002cites this paper
• Microarray analysis of corneal fibroblast gene expression after interleukin-1 treatment.

  2002cites this paper
• Leukotriene C4 Synthase

  2002cites this paper
• Prostaglandins and leukotrienes: advances in eicosanoid biology.

  2001cites this paper
• Anti-leukotrienes for asthma.

  2001cites this paper
• Non-allergic rhinitis: diagnosis and management

  2001cites this paper
• Mast cell lineage development and phenotypic regulation.

  2001cites this paper