Modifications of the fibroblast growth factor‐2 gene led to a marked enhancement in secretion and stability of the recombinant fibroblast growth factor‐2 protein

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2007-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcb.21136PMID 17243099
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998influential reference
• Translocation of proteins across the endoplasmic reticulum membrane.

  1998cited by this paper
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  1997cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991influential reference
• Mitogenic Effects of Fibroblast Growth Factors in Cultured Fibroblastsa

  1991influential reference
• Interactions of growth factors present in bone matrix with bone cells: effects on DNA synthesis and alkaline phosphatase.

  1990cited by this paper
• Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.

  1988cited by this paper
• Stabilizing basic fibroblast growth factor using protein engineering.

  1988influential reference
• Expression of cDNA encoding human basic fibroblast growth factor in E. coli.

  1987influential reference
• Both normal and tumor cells produce basic fibroblast growth factor

  1986cited by this paper
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  2011cites this paper
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• Critical Reviews in Clinical Laboratory Sciences

  2008cites this paper
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  2008cites this paper
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