Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: A potential colorectal cancer chemopreventative

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Biology & Therapy

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.4161/cbt.9.5.10887PMID 20150770
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bioactivity of the Murex Homeopathic Remedy and of Extracts from an Australian Muricid Mollusc against Human Cancer Cells

  2010cited by this paper
• Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats.

  2010cited by this paper
• Cell cycle, CDKs and cancer: a changing paradigm

  2009cited by this paper
• Natural products and colon cancer: current status and future prospects

  2008cited by this paper
• Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer.

  2008cited by this paper
• Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-κB, and ERK-2

  2008cited by this paper
• Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.

  2008cited by this paper
• The artisanal fishery for muricid gastropods (banded murex and purple dye murex) in the Ria Formosa lagoon (Algarve coast, southern Portugal)

  2008cited by this paper
• Uncovering novel targets for cancer chemoprevention.

  2007cited by this paper
• Sex-Specific Tyrian Purple Genesis: Precursor and Pigment Distribution in the Reproductive System of the Marine Mollusc, Dicathais orbita

  2007cited by this paper
• An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.

  2007cited by this paper
• In vitro cytotoxicity evaluation of some substituted isatin derivatives.

  2007cited by this paper
• Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells.

  2007cited by this paper
• Antitumor Activity of Novel Indirubin Derivatives in Rat Tumor Model

  2007cited by this paper
• From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy.

  2007cited by this paper
• Indirubin Enhances Tumor Necrosis Factor-induced Apoptosis through Modulation of Nuclear Factor-κB Signaling Pathway*

  2006cited by this paper
• Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities.

  2006cited by this paper
• Absence of acute apoptotic response to genotoxic carcinogens in p53‐deficient mice is associated with increased susceptibility to azoxymethane‐induced colon tumours

  2005cited by this paper
• Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

  2005cited by this paper
• Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and study of their effect on the cell cycle.

  2005cited by this paper
• Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells.

  2005cited by this paper
• A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth

  2005cited by this paper
• Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages.

  2005cited by this paper
• Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon.

  2005cited by this paper
• Innovative agents in cancer prevention.

  2005cited by this paper
• Chemoprevention of colorectal cancer

  2004cited by this paper
• American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer.

  2004cited by this paper
• Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.

  2004cited by this paper
• Flavonoid recovery and stability from Ginkgo biloba subjected to a simulated digestion process

  2004cited by this paper
• Hereditary colorectal cancer.

  2003cited by this paper
• GSK-3-selective inhibitors derived from Tyrian purple indirubins.

  2003cited by this paper
• Potential effect of cyclooxygenase-2-specific inhibitors on the prevention of colorectal cancer: a cost-effectiveness analysis.

  2003cited by this paper
• Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats.

  2003cited by this paper
• Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas.

  2003cited by this paper
• Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat.

  2002cited by this paper
• The colonic response to genotoxic carcinogens in the rat: regulation by dietary fibre.

  2002cited by this paper
• Anti-mitotic properties of indirubin-3′-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest

  2001cited by this paper
• Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon.

  2001cited by this paper
• D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity.

  2001cited by this paper
• Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panel.

  2001cited by this paper
• Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

  2001cited by this paper
• Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

  2001cited by this paper
• Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

  2001cited by this paper
• Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

  2001cited by this paper
• Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.

  2000cited by this paper
• Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention.

  2000cited by this paper
• Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats.

  2000cited by this paper
• Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

  1999cited by this paper
• Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling.

  1998cited by this paper
• p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

  1998cited by this paper
• PCNA: structure, functions and interactions

  1997cited by this paper
• Incidence and patterns of recurrence following curative resection for colorectal carcinoma

  1997cited by this paper
• Early Alterations of Apoptosis and Cell Proliferation in Azoxymethane‐initiated Rat Colonic Epithelium

  1996cited by this paper
• Model systems for intestinal lymphatic transport studies.

  1996cited by this paper
• Oral colon-specific drug delivery: a review

  1995cited by this paper
• Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation.

  1994cited by this paper
• A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

  1991cited by this paper
• The detection of alkylation damage in the DNA of human gastrointestinal tissues.

  1991cited by this paper
• Hereditary Colorectal Cancer

  1990cited by this paper
• 1,2-Dimethylhydrazine-induced nuclear aberrations in A/J and C57BL/6J mouse colonic crypts.

  1987cited by this paper
• Mechanisms of carcinogenesis induced by alkylating agents.

  1985cited by this paper
• Formation of O6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine.

  1977cited by this paper

• Exploring the therapeutic potential of scorpion venom to mitigate colorectal cancer biomarkers in rats

  2025cites this paper
• Mollusc-Derived Brominated Indoles for the Selective Inhibition of Cyclooxygenase: A Computational Expedition

  2021cites this paper
• Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

  2020cites this paper
• Mapping insoluble indole metabolites in the gastrointestinal environment of a murine colorectal cancer model using desorption/ionisation on porous silicon imaging

  2019cites this paper
• Ocean climate impacts on the primary and secondary metabolites of a muricid mollusc

  2018cites this paper
• Effect of cooking on nutrient composition and anticancer indoles of the marine whelk Dicathais orbita - Can it be another high-value seafood product?

  2018cites this paper
• Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc–Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer

  2017influential citation
• Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury

  2017cites this paper
• An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

  2017cites this paper
• In vitro and in vivo anti-inflammatory activity of extracts from a marine mollusc

  2017influential citation
• Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis

  2017cites this paper
• Anti-Inflammatory Activity and Structure-Activity Relationships of Brominated Indoles from a Marine Mollusc

  2017cites this paper
• Extraction and Quantification of Bioactive Tyrian Purple Precursors: A Comparative and Validation Study from the Hypobranchial Gland of a Muricid Dicathais orbita

  2016cites this paper
• Transcriptome of the Australian Mollusc Dicathais orbita Provides Insights into the Biosynthesis of Indoles and Choline Esters

  2016cites this paper
• Putative role for bacterial symbionts in the biosynthetic origin of Tyrian purple in Dicathais orbita , a Muricidae mollusc

  2016influential citation
• Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats

  2015cites this paper
• Characterization of Bacterial Communities Associated with the Tyrian Purple Producing Gland in a Marine Gastropod

  2015cites this paper
• Retraction notice to "Antimicrobial secondary metabolites from marine gastropod egg capsules and egg masses".

  2015cites this paper
• Chronic inflammation and the development of malignancy in the GI tract.

  2015cites this paper
• Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds?

  2015cites this paper
• Solvent Separating Secondary Metabolites Directly from Biosynthetic Tissue for Surface-Assisted Laser Desorption Ionisation Mass Spectrometry

  2015cites this paper
• ASSESSMENT OF IN VITRO ANTICANCER ACTIVITY OF THE MARINE GASTROPOD CYPRAEA ARABICA (L.1758)

  2015cites this paper
• Indole-Producing Bacteria from the Biosynthetic Organs of a Muricid Mollusc Could Contribute to Tyrian Purple Production

  2015cites this paper
• Supercritical CO2 extraction of bioactive Tyrian purple precursors from the hypobranchial gland of a marine gastropod

  2014cites this paper
• An in vitro high‐throughput assay for screening reproductive and toxic effects of anticancer compounds

  2014cites this paper
• 6-Bromoisatin Found in Muricid Mollusc Extracts Inhibits Colon Cancer Cell Proliferation and Induces Apoptosis, Preventing Early Stage Tumor Formation in a Colorectal Cancer Rodent Model

  2013cites this paper
• Natural Product Research in the Australian Marine Invertebrate Dicathais orbita

  2013cites this paper
• Purified Brominated Indole Derivatives from Dicathais orbita Induce Apoptosis and Cell Cycle Arrest in Colorectal Cancer Cell Lines

  2013cites this paper
• Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs

  2013cites this paper
• Antimicrobial secondary metabolites from marine gastropod egg capsules and egg masses.

  2012cites this paper
• Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

  2012cites this paper
• From Tyrian Purple to Kinase Modulators: Naturally Halogenated Indirubins and Synthetic Analogues

  2012cites this paper
• Mass spectrometry imaging on porous silicon: investigating the distribution of bioactives in marine mollusc tissues.

  2012cites this paper
• Can indole-based extracts prevent colorectal cancer via early apoptotic pathways?

  2010cites this paper