Association of Vitamin D Supplementation in Cardiorespiratory Fitness and Muscle Strength in Adult Twins: A Randomized Controlled Trial.

Although vitamin D is related to cardiorespiratory fitness and muscle strength, there is no evidence in the literature about the genetic influence of the response to vitamin D supplementation and improvements in these parameters. Therefore, we evaluate the effect of longitudinal supplementation of vitamin D on parameters of physical fitness in monozygotic twins. In total, 74 participants were included, with a mean age of 25 years, divided into two groups, one group received supplementation with cholecalciferol for 60 days and the other group did not. Cardiorespiratory fitness and muscle strength were measured before and after supplementation through maximal treadmill tests and dynamometry, respectively. Wilcoxon tests were used to compare intragroup results and the Mann-Whitney test to examine intergroup differences. There was an increase in the serum concentration of vitamin D in participants who ingested the supplementation. Cardiorespiratory fitness improved after supplementation through increases in the values of maximum oxygen consumption of 28% (p < .001). Muscle strength in left hand grip increased 18% in participants who received the supplement (p = .007). Sixty days of cholecalciferol supplementation improved cardiorespiratory fitness and upper limb muscle strength.

• Publication year

  2020

• Venue

  International Journal of Sport Nutrition & Exercise Metabolism

• Publication date

  2020-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.21203/rs.3.rs-116070/v1PMID 34689128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2017cited by this paper
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  2017cited by this paper
• Vitamin D and Muscle Weakness.

  2017cited by this paper
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  2017cited by this paper
• Effects of Vitamin D Supplementation on Muscle Strength in Athletes: A Systematic Review

  2016cited by this paper
• Twin-sibling study and meta-analysis on the heritability of maximal oxygen consumption.

  2016influential reference
• focused update : clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations

  2016cited by this paper
• Strength measures are better than muscle mass measures in predicting health-related outcomes in older people: time to abandon the term sarcopenia?

  2016cited by this paper
• Dietary Reference Intakes for Calcium and Vitamin D

  2016influential reference
• Muscle Strength, Physical Activity, and Functional Limitations in Older Adults with Central Obesity

  2016cited by this paper
• Vitamin D: Recent Advances and Implications for Athletes

  2015cited by this paper
• Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial

  2015cited by this paper
• Grip strength and mortality.

  2015cited by this paper
• Suppression of iron-regulatory hepcidin by vitamin D.

  2014cited by this paper
• Past, present and future of cardiovascular twin studies

  2014cited by this paper
• A Predictive Equation to Guide Vitamin D Replacement Dose in Patients

  2014cited by this paper
• Is exercise used as medicine? Association of meeting strength training guidelines and functional limitations among older US adults.

  2014cited by this paper
• Vitamin D status and ill health: a systematic review.

  2014cited by this paper
• The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Effects of an Iron or Iron and Vitamin D–Fortified Flavored Skim Milk on Iron Metabolism: A Randomized Controlled Double-Blind Trial in Iron-Deficient Women

  2013cited by this paper
• The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

  2012cited by this paper
• Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes.

  2012cited by this paper
• Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.

  2011cited by this paper
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  2010cited by this paper
• A Randomized Controlled Trial of the Effects of Vitamin D on Muscle Strength and Mobility in Older Women with Vitamin D Insufficiency

  2010cited by this paper
• Vitamin D deficiency and myocardial structure and function in older men and women: the Hoorn study.

  2010cited by this paper
• Vitamin D deficiency and myocardial structure and function in older men and women: The Hoorn Study

  2010cited by this paper
• Normative data on hand grip strength in a Greek adult population

  2009cited by this paper
• Muscular strength and mortality in men.

  2009cited by this paper
• Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis.

  2009cited by this paper
• Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.

  2008cited by this paper
• Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography.

  2008cited by this paper
• Vitamin D and human health: lessons from vitamin D receptor null mice.

  2008cited by this paper
• Low cardiorespiratory fitness is a strong predictor for clustering of cardiovascular disease risk factors in children independent of country, age and sex

  2007cited by this paper
• Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse.

  2007cited by this paper
• Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102.

  2006cited by this paper
• Hand-grip strength or muscle mass in cirrhotic patients: Who is the best?

  2006cited by this paper
• Handgrip dynamometry in healthy adults.

  2005cited by this paper
• A practical posture for hand grip dynamometry in the clinical setting.

  2005cited by this paper
• Relationships between structural and functional measures of nutritional status in a normally nourished population.

  2005cited by this paper
• Vitamin D deficiency and muscle weakness in the elderly.

  2005cited by this paper
• Hand grip strength in patients with type 2 diabetes mellitus.

  2005cited by this paper
• The effects of calcitriol on falls and fractures and physical performance tests.

  2004cited by this paper
• Reliability and validity of the DynEx dynamometer.

  2004influential reference
• Average versus Maximum Grip Strength: Which is more Consistent?

  2004cited by this paper
• Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.

  2004cited by this paper
• Zygosity diagnosis in young twins by questionnaire for twins' mothers and twins' self-reports.

  2004influential reference
• Effects of the amount and intensity of exercise on plasma lipoproteins.

  2002cited by this paper
• Walking compared with vigorous exercise for the prevention of cardiovascular events in women.

  2002cited by this paper
• Vitamin D and Muscle Function

  2002cited by this paper
• A comparison of dominant and non dominant hand strengths.

  2001cited by this paper
• Individual differences in response to regular physical activity.

  2001cited by this paper
• Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement

  2000cited by this paper
• A Comparison of Dominant and Non-Dominant Hand Strengths

  1999cited by this paper
• Age-related changes in upper extremity performance of elderly people: a longitudinal study.

  1999cited by this paper
• ACSM's Guidelines for Exercise Testing and Prescription

  1995cited by this paper
• A study of twins.

  1977cited by this paper

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  2023cites this paper
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  2022cites this paper
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