The low cytotoxic activity of peripheral blood NK cells may relate to unexplained recurrent miscarriage

Yongnu Zhang,Chunyu Huang,Ruochun Lian,Jian Xu,Yunfeng Fu,Yong Zeng,W. Tu

Published 2021 in American Journal of Reproductive Immunology

ABSTRACT

Unexplained recurrent miscarriage (uRM) is defined as two or more spontaneous abortions prior to 20 weeks of gestation with unknown etiology. Peripheral blood natural killer (pNK) cells contact with the villus and exert important role in normal pregnancy. However, it is still controversial about the association between pNK cytotoxicity and uRM, and the underlying mechanism remains unknown so far.

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