Integrase-defective lentiviral-vector-based vaccine: a new vector for induction of T cell immunity

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Expert Opinion on Biological Therapy

• Publication date

  2011-05-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1517/14712598.2011.571670PMID 21434847
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MUCOSAL IMMUNITY AND VACCINES

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  2010influential reference
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  2007influential reference
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• Sublingual immunization induces broad-based systemic and mucosal immune responses in mice.

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  2005cited by this paper
• Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines.

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• Mucosal immunity and vaccines

  2005cited by this paper
• Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors.

  2005cited by this paper
• Adenoviruses as vaccine vectors

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• Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells

  2004cited by this paper
• Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland.

  2004cited by this paper
• Recent developments and current status of gene therapy using viral vectors in the United Kingdom

  2004cited by this paper
• Gene-based vaccines and immunotherapeutics

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  2003cited by this paper
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  1999cited by this paper
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