Staphylococcal exotoxins exert proinflammatory effects through inhibition of eosinophil apoptosis, increased surface antigen expression (CD11b, CD45, CD54, and CD69), and enhanced cytokine-activated oxidative burst, thereby triggering allergic inflammatory reactions.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Allergy and Clinical Immunology

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1067/MAI.2002.121702PMID 11897995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The interaction of human peripheral blood eosinophils with bacterial lipopolysaccharide is CD14 dependent.

  2001cited by this paper
• Signaling through the β2 integrin prolongs eosinophil survival

  2000cited by this paper
• Delayed eosinophil apoptosis in asthma.

  2000cited by this paper
• Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB)

  2000cited by this paper
• Eosinophil apoptosis in induced sputum from patients with seasonal allergic rhinitis and with asymptomatic and symptomatic asthma.

  2000cited by this paper
• Atopic dermatitis: new insights and opportunities for therapeutic intervention.

  2000cited by this paper
• Signaling through the beta2 integrin prolongs eosinophil survival.

  2000cited by this paper
• Ligation of CD45 and the isoforms CD45RA and CD45RB accelerates the rate of constitutive apoptosis in human eosinophils.

  1999cited by this paper
• Eosinophil apoptosis is mediated by stimulators of cellular oxidative metabolisms and inhibited by antioxidants: involvement of a thiol-sensitive redox regulation in eosinophil cell death.

  1999cited by this paper
• Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis.

  1999cited by this paper
• Overexpression of CD11b on Eosinophils in Atopic Dermatitis: Downregulation by Cyclosporin A and Upregulation by Interleukin 5

  1999cited by this paper
• Effects of Staphylococcal Enterotoxins on Human Neutrophil Functions and Apoptosis

  1999cited by this paper
• Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis.

  1999cited by this paper
• Possible influences of Staphylococcus aureus on atopic dermatitis — the colonizing features and the effects of staphylococcal enterotoxins

  1999cited by this paper
• Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis.

  1999cited by this paper
• Significant Delay of Apoptosis and Fas Resistance in Eosinophils of Subjects with Intrinsic and Extrinsic Type of Atopic Dermatitis

  1999cited by this paper
• Atopic dermatitis

  1998cited by this paper
• IL-4-induced apoptosis in peripheral blood eosinophils.

  1998cited by this paper
• Activation of human T cells with superantigen (staphylococcal enterotoxin B) and CD28 confers resistance to apoptosis via CD95.

  1998cited by this paper
• CD44 and CD69 represent different types of cell-surface activation markers for human eosinophils.

  1998cited by this paper
• Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics.

  1998cited by this paper
• Altered Expression of CD11b and CD62L after Cross-Linking of CD45 Isoforms on Human Eosinophils

  1998cited by this paper
• Delayed eosinophil programmed cell death in vitro: a common feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis.

  1997cited by this paper
• Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis.

  1996cited by this paper
• Modulation of intercellular adhesion molecule 1 (ICAM‐1) expression on the human mast‐cell line (HMC)‐1 by inflammatory mediators

  1996cited by this paper
• Cutaneous exposure to the superantigen staphylococcal enterotoxin B elicits a T-cell-dependent inflammatory response.

  1996cited by this paper
• Prevalence of producers of enterotoxins and toxic shock syndrome toxin-1 amongStaphylococcus aureus strains isolated from atopic dermatitis lesions

  1996cited by this paper
• Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis.

  1996cited by this paper
• Activation of human eosinophils by IL-13. Induction of CD69 surface antigen, its relationship to messenger RNA expression, and promotion of cellular viability.

  1996cited by this paper
• No difference in enterotoxin production among Staphylococcus aureus strains isolated from blood compared with strains isolated from healthy carriers.

  1995cited by this paper
• Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin‐1 in peripheral blood mononuclear cells from patients with atopic dermatitis

  1995cited by this paper
• Intracellular and surface distribution of CD9 in human eosinophils

  1995cited by this paper
• Cross-linking of CD45 enhances activation of the respiratory burst in response to specific stimuli in human phagocytes.

  1995cited by this paper
• C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins.

  1994cited by this paper
• Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils

  1994cited by this paper
• Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.

  1993cited by this paper
• Superantigenic exotoxin‐secreting potential of staphylococci isolated from atopic eczematous skin

  1993cited by this paper
• Induction of intercellular adhesion molecule 1 (ICAM-1) expression in normal human eosinophils by inflammatory cytokines.

  1993cited by this paper
• CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines.

  1993cited by this paper
• Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis

  1992cited by this paper
• Staphylococcal enterotoxin B: immunolabeling and visualization of target cells.

  1991cited by this paper
• A new method for measuring eosinophil activating factors, based on the increased expression of CR3 alpha chain (CD11b) on the surface of activated eosinophils.

  1990cited by this paper
• The staphylococcal enterotoxins and their relatives.

  1990cited by this paper
• Mature human eosinophils have the capacity to express HLA-DR.

  1989cited by this paper
• A single-photon imaging system for the simultaneous quantitation of luminescent emissions from multiple samples.

  1988cited by this paper
• Characterization of the lipopolysaccharide from the polymyxin‐resistant pmrA mutants of Salmonella typhimurium

  1981cited by this paper
• Diagnostic Features of Atopic Dermatitis

  1980cited by this paper
• Staphylococcal infections in patients with atopic dermatitis.

  1977cited by this paper
• Staphylococcus aureus in the lesions of atopic dermatitis

  1974cited by this paper

• Unraveling the Underlying Comorbidity Mechanisms of Atopic Dermatitis and Periodontitis via Bioinformatics

  2025cites this paper
• Microbial perspective on the skin–gut axis and atopic dermatitis

  2024cites this paper
• Unveiling the phyto-restorative potential of ethereal distillates for atopic dermatitis: an advanced therapeutic approach

  2024cites this paper
• Recent Advances in Phytochemical-Based Topical Applications for the Management of Eczema: A Review

  2024cites this paper
• Curative Potency of Medicinal Plants in Management of Eczema: A Conservative Approach

  2022cites this paper
• Staphylococcal Enterotoxin-Specific IgE Sensitization: A Potential Predictor of Fixed Airflow Obstruction in Elderly Asthma

  2022cites this paper
• A cross-sectional study evidences regulations of leukocytes in the colostrum of mothers with obesity

  2022cites this paper
• Cellular immune response of Staphylococcus aureus enterotoxin B in Balb/c mice through intranasal infection

  2022cites this paper
• Insights into the trafficking of human leukocytes to colostrum evidences a modulation of the B lymphocyte compartment in obesity

  2021cites this paper
• Potent Anti-Inflammatory Effects of Tetracyclines on Human Eosinophils

  2021influential citation
• Assays of Eosinophil Apoptosis and Phagocytic Uptake.

  2021cites this paper
• Can the sensitisation to staphylococcal enterotoxin predict the severity of chronic rhinosinusitis?

  2021cites this paper
• The pseudoallergen receptor MRGPRX2 on peripheral blood basophils and eosinophils: Expression and function

  2020cites this paper
• Time-resolved dual RNA-seq of tissue uncovers Pseudomonas plecoglossicida key virulence genes in host-pathogen interaction with Epinephelus coioides.

  2019cites this paper
• Eosinophils: Nemeses of Pulmonary Pathogens?

  2019cites this paper
• Staphylococcus Aureus in chronic airway diseases: An overview.

  2019cites this paper
• Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

  2019cites this paper
• Are neutrophil, platelet and eosinophil-to-lymphocyte ratio and red blood cell distribution width can be used for nasal polyposis?

  2018cites this paper
• Impaired CD23 and CD62L expression and tissue inhibitors of metalloproteinases secretion by eosinophils in adults with atopic dermatitis

  2016cites this paper
• sCD48 is anti‐inflammatory in Staphylococcus aureus Enterotoxin B‐induced eosinophilic inflammation

  2016cites this paper
• STAPHYLOCOCCUS AUREUS AND THE SKIN MICROBIOME IN ATOPIC DERMATITIS

  2015cites this paper
• A retrospective study on the effect of immunotherapy treatment on nasal polyposis.

  2014cites this paper
• The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation

  2014cites this paper
• Assays of eosinophil apoptosis and phagocytic uptake.

  2014cites this paper
• Staphylococcus aureus enterotoxins A and B inhibit human and mice eosinophil chemotaxis and adhesion in vitro.

  2014cites this paper
• Novel Formable PVA-Based Gel as a Potential for Atopic Dermatitis Treatment

  2014cites this paper
• Modulation of Innate Immune Cell Signaling Pathways by Staphylococcus aureus and Omnigen-AF®

  2013cites this paper
• Can microbial superantigens influence atopic dermatitis flares?

  2012cites this paper
• Local inflammation in chronic upper airway disease.

  2012cites this paper
• Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8.

  2012cites this paper
• Staphylococcus aureus directly activates eosinophils via platelet‐activating factor receptor

  2012cites this paper
• The effect of Staphylococcus aureus on apoptosis of cultured human osteoblasts

  2011cites this paper
• Mucosal tissue polyclonal IgE is functional in response to allergen and SEB

  2011cites this paper
• Encoding a superantigen by Staphylococcus aureus does not affect clinical characteristics of infected atopic dermatitis lesions

  2010cites this paper
• Leczenie infekcji skóry w atopowym zapaleniu skóry

  2010cites this paper
• Possible acceleration of regression by antibiotic treatment in benign cephalic histiocytosis with infiltration of CD11a/CD11c+ macrophages.

  2010cites this paper
• Superantigens and Allergic Disease

  2009cites this paper
• Cellular and molecular mechanisms in atopic dermatitis.

  2009cites this paper
• Kontakt provokáló faktorok szerepe felnőttkori atópiás dermatitisben

  2009cites this paper
• Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps.

  2008cites this paper
• Experimental therapeutic strategies for thetreatment of atopic dermatitis

  2008cites this paper
• Differential up‐regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects

  2008cites this paper
• Atopic dermatitis.

  2007cites this paper
• The role of microorganisms in atopic dermatitis

  2006cites this paper
• Prospects for Vaccines for Allergic and Other Immunologic Skin Disorders

  2006cites this paper
• Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.

  2006cites this paper
• Atopic dermatitis in children, part 1: epidemiology, clinical features, and complications.

  2006cites this paper
• Allergic manifestations of skin diseases--atopic dermatitis.

  2006cites this paper
• Update on nasal polyps: etiopathogenesis.

  2005cites this paper
• Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects.

  2005cites this paper
• SEB-induced T cell apoptosis in atopic patients--correlation to clinical status and skin colonization by Staphylococcus aureus.

  2005cites this paper
• Staphylococcal Exotoxins and Nasal Polyposis: Analysis of Systemic and Local Responses

  2005cites this paper
• Investigating the steroids and long-acting β2‐agonists combination: why do we need more?

  2004cites this paper
• Aspirin Sensitivity and IgE Antibodies to Staphylococcus aureus Enterotoxins in Nasal Polyposis: Studies on the Relationship

  2004cites this paper
• Advances in mechanisms of allergy.

  2004cites this paper
• Allergen extracts directly mobilize and activate human eosinophils

  2004cites this paper
• T‐helper 2 cytokines attenuate senescent eosinophil activation by the CXCR4 ligand stromal‐derived factor‐1α (CXCL12)

  2004cites this paper
• Advances in allergic skin diseases.

  2003cites this paper
• Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] B.

  2003cites this paper
• Regulation of Human Eosinophil and Neutrophil Apoptosis -with Special Reference to Asthma and Effect of Glucocorticoids and Nitric Oxide

  2003cites this paper
• Hemoadsorption therapy for sepsis syndromes.

  2003cites this paper
• Staphylococcal enterotoxin induced IL‐5 stimulation as a cofactor in the pathogenesis of atopic disease: the hygiene hypothesis in reverse?

  2003cites this paper
• Peptidoglycan Induces Mobilization of the Surface Marker for Activation Marker CD66b in Human Neutrophils but Not in Eosinophils

  2003cites this paper
• New concepts in the pathogenesis of atopic dermatitis.

  2003cites this paper
• Gingivitis : An Inflammatory Periodontal Disease

  year unknowncites this paper