DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2

Here, Kwan et al. investigated the mechanisms connecting cell polarity proteins with intracellular signaling pathways. They found that DLG5 functions as an evolutionarily conserved scaffold and negative regulator of Hippo signaling, demonstrating a direct connection between cell polarity proteins and Hippo that is needed for proper development of multicellular organisms.

• Publication year

  2016

• Venue

  Genes & Development

• Publication date

  2016-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.284539.116PMID 28087714PMCID 5238729
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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