DEVELOPMENT AND UTILIZATION OF PRIMARY HEPATOCYTE CULTURE SYSTEMS TO EVALUATE METABOLISM, DNA BINDING, AND DNA REPAIR OF XENOBIOTICS*

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Drug metabolism reviews (Softcover ed.)

• Publication date

  2000-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1081/DMR-100100561PMID 10711405
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver cell models in in vitro toxicology.

  1998cited by this paper
• Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats.

  1998cited by this paper
• Effects of age and caloric restriction on cell proliferation in hepatocyte cultures from control and hepatectomized Fischer 344 rats.

  1996cited by this paper
• Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes.

  1994cited by this paper
• Cryopreservation and long-term storage of primary rat hepatocytes: Effects on substrate-specific cytochrome P450-dependent activities and unscheduled DNA synthesis

  1993cited by this paper
• Cryopreservation: a reliable method for long-term storage and culture of isolated non-proliferating rat hepatocytes

  1993cited by this paper
• Evidence that DNA repair may not be modified by age or chronic caloric restriction.

  1993cited by this paper
• Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay.

  1993cited by this paper
• Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes.

  1992cited by this paper
• Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

  1991cited by this paper
• Effect of pretreatment with hepatic mixed-function oxidase inducers on the genotoxicity of four rat carcinogens in the hepatocyte/DNA repair assay.

  1990cited by this paper
• Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes.

  1989cited by this paper
• Evaluation of propanil and its N-oxidized derivatives for genotoxicity in the Salmonella typhimurium reversion, Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase, and rat hepatocyte/DNA repair assays

  1988cited by this paper
• Evaluation of propanil and its N-oxidized derivatives for genotoxicity in the Salmonella typhimurium reversion, Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase, and rat hepatocyte/DNA repair assays.

  1988cited by this paper
• Modulation of ultraviolet light‐, ethyl methanesulfonate‐, and 7, 12‐dimethylbenz[a]anthracene‐induced unscheduled dna synthesis by retinol and retinoic acid in the primary rat hepatocyte

  1987cited by this paper
• Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene.

  1987cited by this paper
• Hepatocyte-mediated mutagenicity of mononitrobenzo[a]pyrenes in Salmonella typhimurium strains.

  1986cited by this paper
• Comparison of mutagenicities in a Salmonella reversion assay mediated by uninduced hepatocytes and hepatocytes from rats pretreated for 1 or 5 days with Aroclor 1254.

  1985cited by this paper
• Formation and persistence of arylamine DNA adducts in vivo.

  1985influential reference
• Potentiation of dimethylnitrosamine genotoxicity in rat hepatocytes isolated following ethanol treatment in vivo.

  1984cited by this paper
• Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.

  1984cited by this paper
• Insulin and glucagon's reciprocal mediation of a dual regulation mechanism for pyruvate kinase.

  1984cited by this paper
• Statistical criteria for evaluating chemicals as positive or negative in the hepatocyte/DNA repair assay.

  1983cited by this paper
• Effect of lead on calcium-mediated cell function in the isolated rat hepatocyte.

  1982cited by this paper
• Effect of lead on calcium homeostasis in the isolated rat hepatocyte.

  1982cited by this paper
• The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures.

  1981cited by this paper
• Comparative induction of unscheduled DNA synthesis by physical and chemical agents in non-proliferating primary cultures of rat hepatocytes.

  1980cited by this paper
• 2-acetylaminofluorene-induced unscheduled DNA synthesis in hepatocytes isolated from 3-methylcholanthrene treated rats.

  1978cited by this paper
• Unscheduled DNA synthesis induced by procarcinogens in suspensions and primary cultures of hepatocytes on collagen membranes.

  1978cited by this paper
• DNA repair in primary cultures of rat hepatocytes.

  1978cited by this paper
• Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

  1977cited by this paper
• Preparation of isolated rat liver cells.

  1976cited by this paper
• Carcinogen-induced DNA repair in primary rat liver cell cultures; a possible screen for chemical carcinogens.

  1976cited by this paper
• Adult liver parenchymal cells in primary culture: Characteristics and cell recognition standards

  1974cited by this paper
• Isoenzyme patterns in parenchymal and non-parenchymal cells isolated from regenerating and regenerated rat liver.

  1973cited by this paper

• Protocol for Primary Mouse Hepatocyte Isolation

  2020cites this paper
• PTEN in propofol-induced insulin resistance in mouse primary hepatocytes.

  2018cites this paper
• Maintenance of in vivo induced cytochrome P-450s in hepatocyte monolayers at non freezing temperatures.

  2015cites this paper
• Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

  2015cites this paper
• Protective effect of pretreatment with propofol against tumor necrosis factor-α-induced hepatic insulin resistance.

  2015cites this paper
• Long term culture of genome-stable bipotent progenitor cells from adult human liver

  2014cites this paper
• Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ

  2013cites this paper
• The protective effect of adipose-derived stem cells against liver injury by trophic molecules.

  2013cites this paper
• Correction: Hepatic Lipid Accumulation Alters Global Histone H3 Lysine 9 and 4 Trimethylation in the Peroxisome Proliferator-Activated Receptor Alpha Network

  2012cites this paper
• The use of genomics in model in vitro systems.

  2012cites this paper
• Hepatic Lipid Accumulation Alters Global Histone H3 Lysine 9 and 4 Trimethylation in the Peroxisome Proliferator-Activated Receptor Alpha Network

  2012cites this paper
• Lactoferrin protects against acetaminophen‐induced liver injury in mice

  2010cites this paper
• Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds.

  2010cites this paper
• Short‐term Tests for the Determination of Genotoxic and Carcinogenic Potential of Xenobiotics

  2009cites this paper
• Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes

  2009cites this paper
• Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization

  2009cites this paper
• Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors.

  2008cites this paper
• Differential Effects of Histone Deacetylase Inhibitors in Tumor and Normal Cells—What Is the Toxicological Relevance?

  2005cites this paper
• Current Status of Short-Term Tests for Evaluation of Genotoxicity, Mutagenicity, and Carcinogenicity of Environmental Chemicals and NCEs

  2005cites this paper
• Genotoxicty and mutagenicity.

  2005cites this paper
• 3.7. Genotoxicity and Mutagenicity

  2005cites this paper
• In vitro methods to study chemically-induced hepatotoxicity: a literature review.

  2005cites this paper
• UNIVERSIDAD DE MURCIA

  2003cites this paper
• Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity

  2002cites this paper
• Proteomic evaluation of cell preparation methods in primary hepatocyte cell culture

  2002cites this paper