Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin‐deficient mdx mice and humans

Loss of dystrophin causes oxidative stress and affects nitric oxide synthase‐mediated vascular function in striated muscle. Because tetrahydrobiopterin is an antioxidant and co‐factor for nitric oxide synthase, we tested the hypothesis that tetrahydrobiopterin would be low in mdx mice and humans deficient for dystrophin.

• Publication year

  2021

• Venue

  Acta Physiologica

• Publication date

  2021-02-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/apha.13627PMID 33580591
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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