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Polycomb complexes redundantly maintain epidermal stem cell identity during development

Carmit Bar,Hequn Liu,V. Valdes,Dejian Zhao,Phillip M. Galbo,Jose M. Silva,H. Koseki,D. Zheng,E. Ezhkova

Published 2021 in Genes & Development

ABSTRACT

In this study, Cohen et al. sought to understand the functional contribution of PRC1 and PRC2, which largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3, to gene repression. By using the developing murine epidermis as a paradigm, they uncovered a previously unappreciated functional redundancy between Polycomb complexes, and their findings show how PRC1 and PRC2 function as two independent counterparts, providing a repressive safety net that protects and preserves lineage identity.

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