Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Blood cells

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 3052632
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins.

  2009cited by this paper
• Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes.

  1987cited by this paper
• Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

  1987cited by this paper
• Protein carboxyl methyltransferase facilitates conversion of atypical L-isoaspartyl peptides to normal L-aspartyl peptides.

  1987cited by this paper
• Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase.

  1987cited by this paper
• Partial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase.

  1987cited by this paper
• Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells.

  1987cited by this paper
• Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins.

  1987cited by this paper
• Selective deamidation and enzymatic methylation of seminal ribonuclease.

  1986cited by this paper
• Oxidation as a possible mechanism of cellular aging: vitamin E deficiency causes premature aging and IgG binding to erythrocytes.

  1986cited by this paper
• In vitro deamidation of human triosephosphate isomerase.

  1986cited by this paper
• Chemical conversion of aspartyl peptides to isoaspartyl peptides. A method for generating new methyl-accepting substrates for the erythrocyte D-aspartyl/L-isoaspartyl protein methyltransferase.

  1986cited by this paper
• Age-dependent accumulation of protein residues which can be hydrolyzed to D-aspartic acid in human erythrocytes.

  1986cited by this paper
• The ubiquitin pathway for the degradation of intracellular proteins.

  1986cited by this paper
• Protein carboxyl methyltransferase and methyl acceptor proteins in aging and cataractous tissue of the human eye lens.

  1986cited by this paper
• The mechanisms of irreversible enzyme inactivation at 100C.

  1985cited by this paper
• A new case of hemoglobin Providence (alpha 2 beta 2 82 (EF6) Lys----Asn or Asp) discovered in a French Caucasian family. Structural and functional studies.

  1985cited by this paper
• Isolation and characterization of 101-beta-lysozyme that possesses the beta-aspartyl sequence at aspartic acid-101.

  1985cited by this paper
• Aged human erythrocytes exhibit increased anion exchange.

  1985cited by this paper
• Beta-hairpin families in globular proteins.

  1985cited by this paper
• Nonenzymatic covalent posttranslational modification of proteins in vivo.

  1985cited by this paper
• Protein carboxyl methyltransferases: two distinct classes of enzymes.

  1985cited by this paper
• Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.

  1984cited by this paper
• Synthetic peptide substrates for the erythrocyte protein carboxyl methyltransferase. Detection of a new site of methylation at isomerized L-aspartyl residues.

  1984cited by this paper
• Carboxyl methylation of cytosolic proteins in intact human erythrocytes. Identification of numerous methyl-accepting proteins including hemoglobin and carbonic anhydrase.

  1984cited by this paper
• Minireview. Roles of turnover and repair of macromolecules and supramolecular structural components.

  1983cited by this paper
• Senile Cataracts and Aging Changes in Human Proteins

  1983cited by this paper
• Membrane protein carboxyl methylation increases with human erythrocyte age. Evidence for an increase in the number of methylatable sites.

  1983cited by this paper
• Human hypoxanthine-guanine phosphoribosyltransferase. Tryptic peptides and post-translational modification of the erythrocyte enzyme.

  1982cited by this paper
• Increased lability of triosephosphate isomerase in progeria and Werner's syndrome fibroblasts.

  1982cited by this paper
• Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins.

  1982cited by this paper
• Altered proteolytic cleavage of human growth hormone as a result of deamidation.

  1981cited by this paper
• Enzymatic reduction of protein-bound methionine sulfoxide.

  1981cited by this paper
• Reversible methylation of cytoskeletal and membrane proteins in intact human erythrocytes.

  1981cited by this paper
• Molecular basis for the accumulation of acidic isozymes of triosephosphate isomerase on aging.

  1981cited by this paper
• Mechanism of deamidation of haemoglobin providence Asn.

  1980cited by this paper
• A new density gradient system for the separation of human red blood cells

  1980cited by this paper
• Aspartic acid racemization in heavy molecular weight crystallins and water insoluble protein from normal human lenses and cataracts.

  1978cited by this paper
• Aspartic acid racemisation in the human lens during ageing and in cataract formation

  1977cited by this paper
• Hemoglobin Providence. A human hemoglobin variant occurring in two forms in vivo.

  1976cited by this paper
• Aspartic acid racemisation in dentine as a measure of ageing

  1976cited by this paper
• Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82.

  1976cited by this paper
• Intracellular protein degradation in mammalian and bacterial cells: Part 2.

  1976cited by this paper
• Aspartic acid racemization in tooth enamel from living humans.

  1975cited by this paper
• Deamidation in vivo of an asparagine residue of rabbit muscle aldolase.

  1972cited by this paper
• Human carbonic anhydrases. II. Some physicochemical properties of native isozymes and of similar isozymes generated in vitro.

  1969cited by this paper

• Advancing Forensic Human Chronological Age Estimation: Biochemical, Genetic, and Epigenetic Approaches from the Last 15 Years: A Systematic Review

  2025cites this paper
• Latest Advances in Structural Insights and Quantification Techniques for Type I Collagen Biomarkers: A path toward standardization?

  2025cites this paper
• Orthogonal Translation for Site-Specific Installation of Post-translational Modifications.

  2024cites this paper
• Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia

  2021cites this paper
• The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes

  2021cites this paper
• Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

  2018cites this paper
• DNA methylation-based age prediction using massively parallel sequencing data and multiple machine learning models.

  2018cites this paper
• Age estimation based on aspartic acid racemization in dentine: what about caries-affected teeth?

  2018cites this paper
• Understanding quasi-apoptosis of the most numerous enucleated components of blood needs detailed molecular autopsy.

  2017cites this paper
• Uncovering Neurodegenerative Protein Modifications via Proteomic Profiling.

  2015cites this paper
• Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

  2014cites this paper
• Structure, function, aging and turnover of aggrecan in the intervertebral disc.

  2014cites this paper
• Accelerated aging of Asp 58 in αA crystallin and human cataract formation.

  2013cites this paper
• Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid.

  2012cites this paper
• Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

  2012cites this paper
• Exploring the utility of genetic markers for predicting biological age.

  2012cites this paper
• Age estimation of bloodstains: a preliminary report based on aspartic acid racemization rate.

  2011cites this paper
• Comparative proteomics reveals deficiency of NHE-1 (Slc9a1) in RBCs from the beta-adducin knockout mouse model of hemolytic anemia.

  2011cites this paper
• Molecular pathology and age estimation.

  2010cites this paper
• Modeling of ligands for native and chiral modified NMDA receptor NR1-binding core

  2008cites this paper
• Altered immunogenicity of isoaspartate containing proteins

  2007cites this paper
• Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*

  2006cites this paper
• CHAPTER 23 – Products of Bone Collagen Metabolism

  2006cites this paper
• Products of Bone Collagen Metabolism

  2006cites this paper
• Age estimation in biopsy specimens of dentin

  2005cites this paper
• A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production 1

  2003cites this paper
• Production Cell Hyperproliferation and Autoantibody A Failure to Repair Self-Proteins Leads to T

  2003cites this paper
• Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins.

  2002cites this paper
• Racemization of aspartic acid in human proteins.

  2002cites this paper
• [Aging at the molecular level exemplified by proteins].

  2001cites this paper
• Use of bioimpedance spectroscopy to estimate body water distribution in rats fed high dietary sulfur amino acids.

  2001cites this paper
• Deamidation as a widespread phenomenon in two‐dimensional polyacrylamide gel electrophoresis of human blood plasma proteins

  2000cites this paper
• Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.

  2000cites this paper
• Biochemical markers of bone turnover in patients with thyroid dysfunctions and in euthyroid controls: a cross-sectional study.

  1999cites this paper
• Biochemical markers of bone turnover in paget's disease of bone

  1999cites this paper
• The Relationships Between the Degree of β-Isomerization of Type I Collagen Degradation Products in the Urine and Aging, Menopause and Osteoporosis with Fractures

  1999cites this paper
• Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase.

  1998cites this paper
• Diagnostic and Prognostic Value of Biochemical Markers in Malignant Bone Disease: A Prospective Study on the Effect of Bisphosphonate on Pain Intensity and Progression of Malignant Bone Disease

  1998cites this paper
• BIOCHEMICAL MARKERS OF BONE TURNOVER: Applications For Osteoporosis

  1998cites this paper
• D-amino acids in aging erythrocytes.

  1998cites this paper
• Decreased β‐Isomerization of the C‐Terminal Telopeptide of Type I Collagen α1 Chain in Paget's Disease of Bone

  1997cites this paper
• Decreased beta-isomerization of the C-terminal telopeptide of type I collagen alpha 1 chain in Paget's disease of bone.

  1997cites this paper
• Characterization of Urinary Degradation Products Derived from Type I Collagen

  1997cites this paper
• Measurement of Bone Degradation Products in Serum Using Antibodies Reactive with an Isomerized Form of an 8 Amino Acid Sequence of the C‐Telopeptide of Type I Collagen

  1997cites this paper
• Identification of osteocalcin as a permanent aging constituent of the bone matrix: basis for an accurate age at death determination.

  1996cites this paper
• Chapter 3 Erythrocyte Aging

  1996cites this paper
• Protein damage and methylation-mediated repair in the erythrocyte.

  1995cites this paper
• Unprecedented transformation of aspartyl peptides by conjugative degradation

  1994cites this paper
• Carboxyl Methylation of Proteins in Kidney Membranes: Implications in the Repair of Damaged Proteins and in Signal Transduction

  1994cites this paper
• Cytosolic serine hydroxymethyltransferase. Deamidation of asparaginyl residues and degradation in Xenopus laevis oocytes.

  1993cites this paper
• KINETICS and MECHANISM of NONENZYMATIC DEAMIDATION of SOY PROTEIN

  1993cites this paper
• Guanine nucleotides stimulate carboxyl methylation of kidney cytosolic proteins.

  1992cites this paper
• Age-related decline in S-adenosylmethionine and protein methyl esterification levels in bovine lenses.

  1992cites this paper
• Protein carboxyl methylation in kidney brush-border membranes.

  1991cites this paper
• Red Blood Cell Aging

  1991influential citation
• Reduced membrane protein methylation in red cells of the McLeod blood group phenotype

  1991cites this paper
• Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.

  1991cites this paper
• Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation.

  1991cites this paper
• Erythrocyte aging: physical and chemical membrane changes.

  1991cites this paper
• Protein car☐yl methylation in kidney brush-border membranes

  1991cites this paper
• Aspartate racemization in synthetic peptides. Part 2. Tendency to racemization of aminosuccinyl residue

  1991cites this paper
• Band 3 protein degradation by calpain is enhanced in erythrocytes of old people.

  1991cites this paper
• Hypotheses on the physiological role of enzymatic protein methyl esterification using human erythrocytes as a model system.

  1991cites this paper
• Human erythrocyte D-aspartyl/L-isoaspartyl methyltransferases: enzymes that recognize age-damaged proteins.

  1991cites this paper
• Purification, gene cloning, and sequence analysis of an L-isoaspartyl protein carboxyl methyltransferase from Escherichia coli.

  1991cites this paper
• Erythrocyte Membrane Changes during Aging in Vivo

  1990cites this paper
• Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase.

  1990cites this paper
• Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.

  1989cites this paper