Zn(OTf)2-catalyzed hydroamination of ynamides with aromatic amines.

The Zn(OTf)2-catalyzed hydroamination of ynamides 2a-2l with aromatic amines 1a-1r was developed. This protocol features broad substrate scope of aromatic amines, good functional group tolerance for ynamides, and excellent regioselectivities. As a result, a variety of substituted amidine compounds 3aa-3oa, 3ab-3al and 3pa-3rk were prepared in moderate to excellent yields and with high regioselectivities.

• Publication year

  2021

• Venue

  Organic and biomolecular chemistry

• Publication date

  2021-03-03

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/d0ob02603dPMID 33656504
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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