Statistical Evidence for a Helical Nascent Chain

We investigate the hypothesis that protein folding is a kinetic, non-equilibrium process, in which the structure of the nascent chain is crucial. We compare actual amino acid frequencies in loops, α-helices and β-sheets with the frequencies that would arise in the absence of any amino acid bias for those secondary structures. The novel analysis suggests that while specific amino acids exist to drive the formation of loops and sheets, none stand out as drivers for α-helices. This favours the idea that the α-helix is the initial structure of most proteins before the folding process begins.

• Publication year

  2021

• Venue

  Biomolecules

• Publication date

  2021-02-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/biom11030357PMID 33652806PMCID 7996779
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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