Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38

Here, Sun et al. sought to understand the significance of eIF4E-RBM38 interaction in controlling p53 activity. They generated multiple RBM38/eIF4E knock-in (KI) cell lines and show that KI of RBM38-S195D or RBM38-Y192C enhances, whereas KI of RBM38-S195K/R/L weakens, the binding of eIF4E to p53 mRNA and subsequently p53 expression and showed that S193D KI mice have a shortened life span and are prone to spontaneous tumors, chronic inflammation, and liver steatosis, thus providing new insights into how the RBM38-eIF4E loop can fine-tune p53 expression.

• Publication year

  2021

• Venue

  Genes & Development

• Publication date

  2021-03-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.346148.120PMID 33664057PMCID 8015715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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