Effect of milacemide, a glycinamide derivative, on the rat brain gamma-aminobutyric acid system.

No abstract is available for this paper.

• Publication year

  1983

• Venue

  Biochemical Pharmacology

• Publication date

  1983-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0006-2952(83)90087-4PMID 6414480
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.

  1982cited by this paper
• The effects of sodium valproate on gamma-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice.

  1982cited by this paper
• Glycine Receptors in the Human Substantia Nigra as Defined by [3H]Strychnine Binding

  1982cited by this paper
• Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice.

  1982cited by this paper
• Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

  1981cited by this paper
• The status of glycine as a supraspinal neurotransmitter.

  1981cited by this paper
• GABAergic denervation of rat substantia nigra: functional and pharmacological properties.

  1980cited by this paper
• Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.

  1980cited by this paper
• Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo.

  1979cited by this paper
• Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of anticonvulsant action.

  1979cited by this paper
• Differential effects of n‐dipropylacetate and amino‐oxyacetic acid on Gm‐aminobutyric acid levels in discrete areas of rat brain 1

  1979cited by this paper
• Aspinous and sparsely-spinous stellate neurons in the visual cortex of rats contain glutamic acid decarboxylase

  1978cited by this paper
• REGIONAL LEVELS OF GABA IN THE BRAIN: RAPID SEMIAUTOMATED ASSAY AND PREVENTION OF POSTMORTEM INCREASE BY 3‐MERCAPTO‐PROPIONIC ACID

  1978cited by this paper
• STUDIES ON THE REGULATION OF GABA SYNTHESIS: SUBSTRATE‐PROMOTED DISSOCIATION OF PYRIDOXAL‐5′‐PHOSPHATE FROM GAD

  1978cited by this paper
• The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

  1977cited by this paper
• THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVO

  1977cited by this paper
• D‐ AND L‐STEREOISOMERS OF ALLYLGLYCINE: CONVULSIVE ACTION AND INHIBITION OF BRAIN L‐GLUTAMATE DECARBOXYLASE

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Immunocytochemical localization of glutamate decarboxylase in rat substantia nigra.

  1976cited by this paper
• Epilepsy and gamma-aminobutyric acid-mediated inhibition.

  1975cited by this paper
• Epilepsy and gamma-aminobutyric acid-mediated inhibition.

  1975cited by this paper
• The in vivo neuropharmacology of amino-oxyacetic acid in the cerebral cortex of the cat.

  1972cited by this paper
• Thein vivo neuropharmacology of amino-oxyacetic acid in the cerebral cortex of the cat

  1972cited by this paper

• Suicide Inhibition of Monoamine Oxidase from Different Species by Milacemide

  2012cites this paper
• Anticonvulsant drug action and regional neurotransmitter amino acid changes

  2005cites this paper
• In silico studies for the rational discovery of anticonvulsant compounds.

  2000cites this paper
• Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.

  1998cites this paper
• The Efficacy and Use of Anticonvulsants in Mood Disorders

  1998cites this paper
• Update on novel antiepileptic drugs

  1997cites this paper
• A microdialysis study of glycinamide, glycine and other amino acid neurotransmitters in rat frontal cortex and hippocampus after the administration of milacemide, a glycine pro-drug

  1996cites this paper
• Antiepileptic drugs and mechanisms of epileptogenesis. A review

  1995cites this paper
• Interactions of some analogues of the anticonvulsant milacemide with monoamine oxidase.

  1994cites this paper
• Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid.

  1993cites this paper
• Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: milacemide

  1993cites this paper
• 3-alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents.

  1992cites this paper
• Effect of milacemide on extracellular and tissue concentrations of dopamine and 5‐hydroxytryptamine in rat frontal cortex

  1992cites this paper
• Effect of Milacemide on Audiogenic Seizures and Cortical (Na+, K+)‐ATPase of DBA/2J Mice

  1991cites this paper
• 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase.

  1991cites this paper
• Is the oxidation of milacemide by monoamine oxidase a major factor in its anticonvulsant actions?

  1991cites this paper
• Modulation of vocal and nonvocal behavior in adult squirrel monkeys by selective MAO-A and MAO-B inhibition.

  1991cites this paper
• Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

  1990cites this paper
• MAO activity, metabolism and anticonvulsant activity of milacemide in rats and mice.

  1990cites this paper
• Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells

  1990cites this paper
• Milacemide stimulates deficient glial Na+, K(+)-ATPase in freezing-induced epileptogenic cortex of cats.

  1990cites this paper
• Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of rhesus monkey.

  1990cites this paper
• Monoamine oxidase inhibitory properties of milacemide in rats.

  1989cites this paper
• Milacemide increases 5-hydroxytryptamine and dopamine levels in rat brain--possible mechanisms of milacemide antimyoclonic property in the p,p'-DDT-induced myoclonus.

  1989cites this paper
• Anticonvulsant activity of milacemide.

  1983cites this paper