Dynamic mechanisms for pre-miRNA binding and export by Exportin-5.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  RNA: A publication of the RNA Society

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1261/rna.2732611PMID 21712399PMCID PMC3153975
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A′-form RNA helices drive microtubule-based mRNA transport in Drosophila

  2010cited by this paper
• Toward a system-level understanding of microRNA pathway via mathematical modeling

  2010cited by this paper
• Mechanism of MicroRNA-Target Interaction: Molecular Dynamics Simulations and Thermodynamics Analysis

  2010cited by this paper
• Structures of the tRNA export factor in the nuclear and cytosolic states

  2009cited by this paper
• Scaling and self-organized criticality in proteins II

  2009cited by this paper
• Scaling and self-organized criticality in proteins I

  2009cited by this paper
• A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

  2009influential reference
• Elucidating the inhibition mechanism of HIV-1 non-nucleoside reverse transcriptase inhibitors through multicopy molecular dynamics simulations.

  2009cited by this paper
• GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.

  2008influential reference
• Molecular dynamics simulations of nucleic acid-protein complexes.

  2008cited by this paper
• Protein–protein recognition and interaction hot spots in an antigen–antibody complex: Free energy decomposition identifies “efficient amino acids”

  2007cited by this paper
• Karyopherin flexibility in nucleocytoplasmic transport.

  2006cited by this paper
• Structural basis for broad DNA-specificity in integron recombination

  2006cited by this paper
• The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding.

  2005cited by this paper
• Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs.

  2004cited by this paper
• Nuclear Export of MicroRNA Precursors

  2004cited by this paper
• Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations

  2003influential reference
• Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.

  2003cited by this paper
• The nuclear RNase III Drosha initiates microRNA processing

  2003cited by this paper
• Asymmetry in the Assembly of the RNAi Enzyme Complex

  2003cited by this paper
• Development of polyphosphate parameters for use with the AMBER force field

  2003cited by this paper
• Nucleocytoplasmic transport: taking an inventory

  2003cited by this paper
• Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle.

  2003cited by this paper
• 3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures.

  2003cited by this paper
• Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.

  2003cited by this paper
• Asymmetry in the assembly of the RNAi enzyme complex.

  2003cited by this paper
• MicroRNA maturation: stepwise processing and subcellular localization

  2002cited by this paper
• Dissecting the molecular origins of specific protein-nucleic acid recognition: hydrostatic pressure and molecular dynamics.

  2002cited by this paper
• The role of residue 50 and hydration water molecules in homeodomain DNA recognition

  2002cited by this paper
• Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells.

  2002cited by this paper
• Equilibrium Information from Nonequilibrium Measurements in an Experimental Test of Jarzynski's Equality

  2002cited by this paper
• Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins

  2002cited by this paper
• Role for a bidentate ribonuclease in the initiation step of RNA interference

  2001cited by this paper
• On the nature of a glassy state of matter in a hydrated protein: Relation to protein function

  2001cited by this paper
• Do water molecules mediate protein-DNA recognition?

  2001cited by this paper
• Dissecting the Vibrational Entropy Change on Protein/Ligand Binding: Burial of a Water Molecule in Bovine Pancreatic Trypsin Inhibitor

  2001cited by this paper
• Imino proton exchange and base-pair kinetics in RNA duplexes.

  2001cited by this paper
• Solvent density and long‐range dipole field around a DNA‐binding protein studied by molecular dynamics

  2000cited by this paper
• Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models.

  2000influential reference
• Dielectric relaxation and solvation dynamics of water in complex chemical and biological systems.

  2000cited by this paper
• Approximate atomic surfaces from linear combinations of pairwise overlaps (LCPO)

  1999cited by this paper
• A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export

  1999cited by this paper
• Free energy of burying hydrophobic residues in the interface between protein subunits.

  1998cited by this paper
• Systematic analysis of domain motions in proteins from conformational change: New results on citrate synthase and T4 lysozyme

  1998cited by this paper
• Locally accessible conformations of proteins: Multiple molecular dynamics simulations of crambin

  1998influential reference
• Exportin 1 (Crm1p) is an essential nuclear export factor.

  1997cited by this paper
• The role of water in protein-DNA interactions.

  1997cited by this paper
• LINCS: A linear constraint solver for molecular simulations

  1997cited by this paper
• Evidence for a role of CRM1 in signal-mediated nuclear protein export.

  1997cited by this paper
• RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

  1997cited by this paper
• Forces contributing to the conformational stability of proteins

  1996cited by this paper
• Nonequilibrium Equality for Free Energy Differences

  1996cited by this paper
• Structure and dynamics of the water around myoglobin

  1995cited by this paper
• Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles.

  1995cited by this paper
• The essential dynamics of thermolysin: Confirmation of the hinge‐bending motion and comparison of simulations in vacuum and water

  1995cited by this paper
• AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules

  1995cited by this paper
• Essential dynamics of the cellular retinol-binding protein--evidence for ligand-induced conformational changes.

  1995cited by this paper
• A Connected‐cluster of hydration around myoglobin: Correlation between molecular dynamics simulations and experiment

  1994cited by this paper
• Distribution function implied dynamics versus residence times and correlations: Solvation shells of myoglobin

  1994cited by this paper
• Essential dynamics of proteins

  1993cited by this paper
• Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

  1993influential reference
• Effects of sequence and length on imino proton exchange and base pair opening kinetics in DNA oligonucleotide duplexes.

  1992cited by this paper
• WHAT IF: a molecular modeling and drug design program.

  1990cited by this paper
• Molecular dynamics with coupling to an external bath

  1984influential reference
• Comparison of simple potential functions for simulating liquid water

  1983cited by this paper

• Targeting microRNAs as Potential Treatments for Respiratory Viruses: Insights and Future Directions.

  2026cites this paper
• MiRNA Stability and Degradation: Dynamic Regulators of Cellular Regulatory Networks

  2026cites this paper
• MicroRNAs as Cancer Biomarkers: Unveiling Diagnostic and Prognostic Potential

  2025cites this paper
• Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427

  2025cites this paper
• The role of miRNAs as biomarkers in breast cancer

  2024cites this paper
• A double-negative feedback loop mediated by non-coding RNAs contributes to tooth morphogenesis.

  2024cites this paper
• Network Pharmacology and Experimental Validation Explore the Pharmacological Mechanisms of Herb Pair for Treating Rheumatoid Arthritis.

  2024cites this paper
• Role of microRNAs in renal cancer diagnostics

  2023cites this paper
• Interrelated grid of non-coding RNA: An important aspect in Rheumatoid Arthritis pathogenesis

  2023cites this paper
• Small molecule-mediated targeting of microRNAs for drug discovery: Experiments, computational techniques, and disease implications

  2023cites this paper
• miR-136-5p: A key player in human cancers with diagnostic, prognostic and therapeutic implications.

  2023cites this paper
• Inherent conformational plasticity in dsRBDs enables interaction with topologically distinct RNAs.

  2022cites this paper
• Circulating microRNAs as the Potential Diagnostic and Prognostic Biomarkers for Nasopharyngeal Carcinoma

  2022cites this paper
• MicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review

  2021cites this paper
• Two Putative Cypovirus-Encoded miRNAs Co-regulate the Host Gene of GTP-Binding Nuclear Protein Ran and Facilitate Virus Replication

  2021cites this paper
• MicroRNAs: From Junk RNA to Life Regulators and Their Role in Cardiovascular Disease

  2021cites this paper
• Alcohol induced impairment/abnormalities in Brain: Role of MicroRNA.

  2021cites this paper
• Decoding nonspecific interactions between human nuclear transport proteins: A computational study

  2021cites this paper
• Micro-RNA: The darkhorse of cancer.

  2021cites this paper
• MicroRNA sequences modulating inflammation and lipid accumulation in macrophage “foam” cells: Implications for atherosclerosis

  2020cites this paper
• The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies

  2020cites this paper
• Host microRNAs and exosomes that modulate influenza virus infection.

  2020cites this paper
• Mixed-lineage leukemia protein modulates the loading of let-7a onto AGO1 by recruiting RAN

  2020cites this paper
• Protective effect of microRNA-381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4

  2020cites this paper
• miRNAs and Muscle Stem Cells

  2020cites this paper
• HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing.

  2020cites this paper
• CREB1/Lin28/miR-638/VASP Interactive Network Drives the Development of Breast Cancer

  2019cites this paper
• Conformational dynamics at microsecond timescale in the RNA-binding regions of dsRNA-binding domains

  2019cites this paper
• Editorial focus: understanding off-target effects as the key to successful RNAi therapy

  2019cites this paper
• Role of protein dynamics in enthalpy-driven recognition of topologically distinct dsRNAs by dsRBDs

  2019cites this paper
• MICROmanagement of Runx2 Function in Skeletal Cells

  2019cites this paper
• CRD1, an Xpo1 domain protein, regulates miRNA accumulation and crown root development in rice.

  2019cites this paper
• Interaction of host and viral microRNAs with infectious laryngotracheitis virus transcripts

  2019cites this paper
• Mitochondrial MiRNA in Cardiovascular Function and Disease

  2019cites this paper
• Epigenetics in teleost fish: From molecular mechanisms to physiological phenotypes.

  2018cites this paper
• microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity.

  2018cites this paper
• Functional Association between Regulatory RNAs and the Annexins

  2018cites this paper
• Reverse Engineering Glaucoma

  2018cites this paper
• miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

  2018cites this paper
• Stochasticity and robustness analysis of microRNA-mediated ERK signaling network

  2018cites this paper
• Molecular dynamics and free energy studies on the Drosophila melanogaster and Leptinotarsa decemlineata ecdysone receptor complexed with agonists: Mechanism for binding and selectivity

  2018cites this paper
• SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation

  2017cites this paper
• Dynamics of miRNA biogenesis and nuclear transport

  2016cites this paper
• Dynamics of miRNA biogenesis and nuclear transport

  2016cites this paper
• Insights into the Structural Dynamics of Nucleocytoplasmic Transport of tRNA by Exportin-t.

  2016cites this paper
• Role of microRNA-21 in atherogenesis.

  2016cites this paper
• Nucleocytoplasmic Transport of RNAs and RNA-Protein Complexes.

  2016cites this paper
• Investigating the regulation of miRNA biogenesis and Argonaute2 by RNA binding proteins

  2016cites this paper
• Investigating the molecular mechanisms and functions of the Musashi-2 RNA-binding protein

  2016cites this paper
• The regulations of miR-30c-3-3p and its antitumor mechanism in ovarian cancer

  2015influential citation
• Improved RT-PCR Assay to Quantitate the Pri-, Pre-, and Mature microRNAs with Higher Efficiency and Accuracy

  2015cites this paper
• Emerging role of microRNA-21 in colorectal cancer

  2015cites this paper
• The crosstalk between miRNA and mammalian circadian clock.

  2015cites this paper
• MicroRNAs in Tissue Engineering and Regenerative Medicine

  2015cites this paper
• MicroRNAs : History , Biogenesis and Modes of Action to Regulate Gene Expression

  2015cites this paper
• Bistable Switch in let-7 miRNA Biogenesis Pathway Involving Lin28

  2014cites this paper
• Functional analysis of ovine herpesvirus 2 encoded microRNAs

  2014cites this paper
• Molecular dynamics simulation in RNA interference.

  2014influential citation
• Augmentation of Ras-induced cell transformation : a new role for miR-200a in malignancy.

  2014cites this paper
• Role of microRNAs in Arbovirus/Vector Interactions

  2014cites this paper
• Global Microrna Gene Expression Profiles Analysis And Possible Role Of Microrna-5p And 3p Pairs In Human Colon Cancer Cells

  2013cites this paper
• The sea urchin seawi and other argonaute family of proteins: it’s a small RNA world after all

  2013cites this paper
• miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: significance of their regulation.

  2013cites this paper
• MicroRNAs in cardiovascular therapeutics.

  2013cites this paper
• miR-34 is maternally inherited in Drosophila melanogaster and Danio rerio

  2013cites this paper
• Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome

  2013cites this paper
• RNA viruses and microRNAs: challenging discoveries for the 21st century.

  2013cites this paper
• MicroRNAs in ischemia-reperfusion injury.

  2012cites this paper
• Molecular dynamics and free energy studies on the carboxypeptidases complexed with peptide/small molecular inhibitor: mechanism for drug resistance.

  2012cites this paper
• Regulating the Exportin-5 Cofactor Ran Suppresses Its Host miRNA Biogenesis by A Baculovirus-Encoded MicroRNA (miRNA)

  2012cites this paper
• Pulmonary arterial hypertension: role of miRNAs in animal models and pathological samples

  2012cites this paper
• Exhaustive exercise such as an Ironman triathlon alters MicroRNA expression pattern in whole blood

  2012cites this paper
• Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction.

  2012cites this paper
• Local and global effects of Mg2+ on Ago and miRNA-target interactions

  2012cites this paper
• Molecular dynamics simulation of conformational heterogeneity in transportin 1

  2012cites this paper
• Understanding the molecular basis of MK2-p38α signaling complex assembly: insights into protein-protein interaction by molecular dynamics and free energy studies.

  2012cites this paper
• Exportin T and Exportin 5: tRNA and miRNA biogenesis – and beyond

  2012cites this paper
• A Baculovirus-Encoded MicroRNA (miRNA) Suppresses Its Host miRNA Biogenesis by Regulating the Exportin-5 Cofactor Ran

  2012cites this paper
• Regulation of let-7 miRNA biogenesis in C. elegans

  2011cites this paper