LIN-41 inactivation leads to delayed centrosome elimination and abnormal chromosome behavior during female meiosis in Caenorhabditis elegans

R. Matsuura,Tomoko Ashikawa,Yuka Nozaki,Daiju Kitagawa

Published 2016 in Molecular Biology of the Cell

ABSTRACT

An RNAi screen in the Caenorhabditis elegans gonad identifies new regulators for centrosome behavior in oogenesis. LIN-41 is found to be a promoter for centrosome elimination in oocytes. Moreover, LIN-41 depletion results in ectopic activation of centrosomes and abnormal chromosome behavior in female meiosis.

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