Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters

The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under mild conditions (visible light, ambient temperature, no strong base) to access the versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities. Metallaphototoredox catalysis has been rarely applied to reductive cross-couplings, in contrast to typical redox-neutral methods. Here, the authors report a mild Ni/photoredox-catalyzed reductive cross-coupling of aryl iodides and α-chloroboranes, further enriching the metallaphotoredox chemistry.

• Publication year

  2021

• Venue

  Nature Communications

• Publication date

  2021-03-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/s41467-021-21947-1PMID 33712612PMCID 7954797
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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