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Impact of Donor Age on Recipient Survival in Adult-to-Adult Living-donor Liver Transplantation

T. Kubota,K. Hata,T. Sozu,Y. Ueda,H. Hirao,Y. Okamura,I. Tamaki,J. Yoshikawa,Jiro Kusakabe,Hirokazu Tanaka,S. Kageyama,T. Anazawa,A. Yoshizawa,S. Yagi,N. Yamashiki,H. Okajima,T. Kaido,S. Uemoto

Published 2017 in Annals of Surgery

ABSTRACT

Objective:To investigate the influence of donor age on recipient outcome after living-donor partial liver transplantation (LDLT). Background:Donor age is a well-known prognostic factor in deceased donor liver transplantation; however, its role in LDLT remains unclear. Methods:We retrospectively analyzed 315 consecutive cases of primary adult-to-adult LDLT in our center between April 2006 and March 2014. Recipients were divided into 5 groups according to the donor age: D-20s (n = 60); D-30s (n = 72); D-40s (n = 57); D-50s (n = 94); and D-60s (n = 32). The recipient survival and the association with various clinical factors were investigated. Results:Recipient survival proportions were significantly higher in D-20s compared with all the other groups (P = 0.008, < 0.001, < 0.001, and = 0.006, vs D-30s, -40s, -50s, and -60s, respectively), whereas there was no association between recipient survival and their own age. There are 3 typical relationships between donors and recipients in adult-to-adult LDLT: from child-to-parent, between spouses/siblings, and from parent-to-child. The overall survival in child-to-parent was significantly higher than in spouses/siblings (P = 0.002) and in parent-to-child (P = 0.005), despite significantly higher recipient age in child-to-parent [59 (42–69) years, P < 0.001]. Contrastingly, parent-to-child exhibited the lowest survival, despite the youngest recipient age [26 (20–43) years, P < 0.001]. In addition, younger donor age exhibited significantly better recipient survival both in hepatitis C virus-related and in non-hepatitis C virus diseases. Univariate and multivariate analyses both demonstrated that donor age and graft-type (right-sided livers) are independent prognostic factors for recipient survival. Conclusions:Donor age is an independent, strong prognostic factor in adult-to-adult LDLT.

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