A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Biophysical Journal

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1529/BIOPHYSJ.105.066092PMID 16227507PMCID PMC1367016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Calmodulin Binding Domain of RyR Increases Activation of Spontaneous Ca2+ Sparks in Frog Skeletal Muscle*

  2005cited by this paper
• Different Regions in Skeletal and Cardiac Muscle Ryanodine Receptors Are Involved in Transducing the Functional Effects of Calmodulin*

  2004cited by this paper
• The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain.

  2004cited by this paper
• Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor.

  2004cited by this paper
• Mutational Analysis of Putative Calcium Binding Motifs within the Skeletal Ryanodine Receptor Isoform, RyR1*

  2004influential reference
• RyR1 exhibits lower gain of CICR activity than RyR3 in the SR: evidence for selective stabilization of RyR1 channel.

  2004cited by this paper
• A Noncontiguous, Intersubunit Binding Site for Calmodulin on the Skeletal Muscle Ca2+ Release Channel*

  2003cited by this paper
• Identification of a Key Determinant of Ryanodine Receptor Type 1 Required for Activation by 4-Chloro-m-cresol*

  2003cited by this paper
• Lobe-dependent Regulation of Ryanodine Receptor Type 1 by Calmodulin*

  2002cited by this paper
• Calcium-binding proteins.

  2002cited by this paper
• Molecular dissection, tissue localization and Ca2+ binding of the ryanodine receptor of Caenorhabditis elegans.

  2002cited by this paper
• Coupling of RYR1 and L-type calcium channels via calmodulin binding domains.

  2001cited by this paper
• Calcium Binding to Calmodulin Leads to an N-terminal Shift in Its Binding Site on the Ryanodine Receptor*

  2001cited by this paper
• Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels*

  2001cited by this paper
• Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine

  2001cited by this paper
• The carboxy-terminal calcium binding sites of calmodulin control calmodulin's switch from an activator to an inhibitor of RYR1.

  2001cited by this paper
• Regulation of RYR1 activity by Ca(2+) and calmodulin.

  2000cited by this paper
• Determinants for Calmodulin Binding on Voltage-dependent Ca2+ Channels*

  2000cited by this paper
• Characterization of a calcium-regulation domain of the skeletal-muscle ryanodine receptor.

  2000cited by this paper
• Ca2+ Inactivation Sites Are Located in the COOH-terminal Quarter of Recombinant Rabbit Skeletal Muscle Ca2+ Release Channels (Ryanodine Receptors)*

  1999cited by this paper
• A Role for Cysteine 3635 of RYR1 in Redox Modulation and Calmodulin Binding*

  1999cited by this paper
• Modulation of Ca2+-gated cardiac muscle Ca2+-release channel (ryanodine receptor) by mono- and divalent ions.

  1998cited by this paper
• Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha1C subunit.

  1998cited by this paper
• Molecular Determinants of L-type Ca2+ Channel Inactivation

  1998cited by this paper
• Identification of a two EF-hand Ca2+ binding domain in lobster skeletal muscle ryanodine receptor/Ca2+ release channel.

  1998cited by this paper
• Regulation of Skeletal Muscle Ca2+ Release Channel (Ryanodine Receptor) by Ca2+ and Monovalent Cations and Anions*

  1997cited by this paper
• Circular Dichroism and the Conformational Analysis of Biomolecules

  1996cited by this paper
• Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor).

  1995cited by this paper
• Identification of calmodulin-, Ca(2+)-, and ruthenium red-binding domains in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

  1994cited by this paper
• Identification of the domain recognized by anti-(ryanodine receptor) antibodies which affect Ca(2+)-induced Ca2+ release.

  1993cited by this paper
• Antibodies as probes for Ca2+ activation sites in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

  1993cited by this paper
• Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain

  1992cited by this paper
• Characterization of a Ca2+ binding and regulatory site in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

  1992cited by this paper
• Primary structure and functional expression from cDNA of the cardiac ryanodine receptor/calcium release channel

  1991cited by this paper
• Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel.

  1990cited by this paper
• Primary structure and functional expression from cDN A of the cardiac ryanodine receptor/calcium release channel

  1990cited by this paper
• Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

  1990cited by this paper
• Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

  1989cited by this paper
• A procedure for purification of the ryanodine receptor from skeletal muscle.

  1989cited by this paper
• Calcium-binding proteins.

  1976cited by this paper
• Evolution and function of calcium-binding proteins.

  1976cited by this paper
• Disruption of low- and high-density human plasma lipoproteins and phospholipid dispersions by 1-anilinonaphthalene-8-sulfonate.

  1971cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Structural and functional interactions between the EF hand domain and S2–S3 loop in the type-1 ryanodine receptor ion channel

  2023cites this paper
• Prenatal diagnosis identifies compound heterozygous variants in RYR1 that causes ultrasound abnormalities in a fetus

  2022cites this paper
• Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease

  2022cites this paper
• An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity

  2022cites this paper
• RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation

  2021cites this paper
• Mechanistic link between between CaM-RyR2 interactions and the genesis of cardiac arrhythmia.

  2021influential citation
• The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.

  2021cites this paper
• Calcium Release Channels: Structure and Function of IP3 Receptors and Ryanodine Receptors.

  2021cites this paper
• Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels.

  2020cites this paper
• Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target

  2020cites this paper
• Investigating dual Ca2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation

  2019cites this paper
• Elucidating Effects of RYR1 in a Zebrafish Model and a Novel Recessive Mouse Model

  2019cites this paper
• Ryanodine Receptor Structure and Function in Health and Disease.

  2018cites this paper
• Membrane Protein Complexes: Structure and Function

  2018cites this paper
• Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.

  2018cites this paper
• Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin.

  2017influential citation
• Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism.

  2017cites this paper
• The structural basis of ryanodine receptor ion channel function

  2017cites this paper
• Lanthanides Report Calcium Sensor in the Vestibule of Ryanodine Receptor.

  2017cites this paper
• JGP_201711878 1065..1090

  2017cites this paper
• Ryanodine receptors under the magnifying lens: Insights and limitations of cryo-electron microscopy and X-ray crystallography studies.

  2016cites this paper
• Structural Basis for Gating and Activation of RyR1.

  2016cites this paper
• The effects of RYR2 gene deletion on cardiac function and metabolism

  2016cites this paper
• Characterisation of a novel interaction between the cardiac myosin binding protein-C and the ryanodine receptor/calcium release channel

  2016cites this paper
• Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation.

  2016cites this paper
• Structural characterization of calmodulin like domain of ryanodine receptor type 1

  2015cites this paper
• Structural and functional interactions within ryanodine receptor.

  2015cites this paper
• Ryanodine receptors: allosteric ion channel giants.

  2015cites this paper
• The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor*

  2015cites this paper
• Structure of a mammalian ryanodine receptor

  2014cites this paper
• Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1).

  2014cites this paper
• Lobe-specific calmodulin binding to different ryanodine receptor isoforms.

  2014cites this paper
• Two Regions of the Ryanodine Receptor Calcium Channel Are Involved in Ca2+-Dependent Inactivation

  2014cites this paper
• Structural analysis of the mechanisms underlying ryanodine receptor-mediated dysfunction leading to cardiac arrhythmias

  2014cites this paper
• Characterisation of inter-subunit interactions within cardiac ryanodine receptor

  2014influential citation
• Structural Studies of the Ryanodine Receptor and Its Binding Protein, Calstabin

  2014cites this paper
• Calmodulin as a universal regulator of voltage gated calcium channels

  2014cites this paper
• Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor

  2014cites this paper
• Probe Ca2+/Camodulin reguation of membrane proteins engineering

  2013cites this paper
• Skeletal muscle fatigue – regulation of excitation–contraction coupling to avoid metabolic catastrophe

  2012influential citation
• Dissecting key determinants for calcium and calmodulin regulation of gap junction and viral protein

  2012cites this paper
• Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif

  2012cites this paper
• Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.

  2012influential citation
• Mapping domains and mutations on the skeletal muscle ryanodine receptor channel.

  2012cites this paper
• The IQ Motif is Crucial for Cav1.1 Function

  2011cites this paper
• Tuning calcium binding affinities and related biological fuctions of calmodulin and designing protein based contrast agent

  2011cites this paper
• Ryanodine receptor assembly: a novel systems biology approach to 3D mapping.

  2011cites this paper
• Research Article The IQ Motif is Crucial for Ca v 1.1 Function

  2011cites this paper
• Ryanodine receptor type I

  2011cites this paper
• Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte.

  2011cites this paper
• Bioinformatics Domain Structure Prediction and Homology Modeling of Human Ryanodine Receptor 2

  2011cites this paper
• Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.

  2010cites this paper
• Ryanodine receptor-mediated arrhythmias and sudden cardiac death

  2009cites this paper
• Ryanodine Receptor Structure: Progress and Challenges*

  2009cites this paper
• 25 Insights into the Three-Dimensional Organization of Ryanodine Receptor

  2009cites this paper
• Determinants in CaV1 Channels That Regulate the Ca2+ Sensitivity of Bound Calmodulin*

  2009cites this paper
• Interaction of the Lys(3614)-Asn(3643) calmodulin-binding domain with the Cys(4114)-Asn(4142) region of the type 1 ryanodine receptor is involved in the mechanism of Ca2+/agonist-induced channel activation.

  2008cites this paper
• Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.

  2008cites this paper
• Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release.

  2008cites this paper
• A calmodulin antagonist reveals a calmodulin-independent interdomain interaction essential for activation of inositol 1,4,5-trisphosphate receptors.

  2008cites this paper
• Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies.

  2007cites this paper
• Modulation of the ryanodine receptor and intracellular calcium.

  2007cites this paper
• Centronuclear myopathy due to a de novo dominant mutation in the skeletal muscle ryanodine receptor (RYR1) gene.

  2007cites this paper
• Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies.

  2007cites this paper
• Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism.

  2007cites this paper
• Ryanodine receptor structure, function and pathophysiology

  2007cites this paper
• Structural Determinants of 4-Chloro-m-cresol Required for Activation of Ryanodine Receptor Type 1

  2006cites this paper
• Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide.

  2006cites this paper
• Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode.

  2006cites this paper