First‐trimester serum BAFF:sFlt‐1 ratio as a candidate early biomarker of spontaneous abortion

Immunologic, angiogenic, and anti‐angiogenic factors are associated with spontaneous abortion (SAB). B cell–activating factor (BAFF), a proliferation‐inducing ligand (APRIL), placental growth factor (PlGF), and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) may play a role in SAB and may serve singly or in combination as an early biomarker of SAB.

• Publication year

  2021

• Venue

  American Journal of Reproductive Immunology

• Publication date

  2021-04-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/aji.13428PMID 33837577
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Maternal Serum B-Cell Activating Factor Levels: Candidate Early Biomarker for Hypertensive Disorders of Pregnancy

  2017cited by this paper
• Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.

  2016cited by this paper
• Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage.

  2016cited by this paper
• The sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.

  2016cited by this paper
• Placental growth factor, soluble fms-like tyrosine kinase 1 and progesterone as diagnostic biomarkers for ectopic pregnancy and missed abortion.

  2014cited by this paper
• Risk of miscarriage among black women and white women in a U.S. Prospective Cohort Study.

  2013cited by this paper
• Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

  2013cited by this paper
• Serum Concentrations of Soluble Flt-1 Are Decreased among Women with a Viable Fetus and No Symptoms of Miscarriage Destined for Pregnancy Loss

  2012cited by this paper
• A systematic review to calculate background miscarriage rates using life table analysis.

  2012cited by this paper
• Soluble Flt-1 and PlGF: New Markers of Early Pregnancy Loss?

  2011cited by this paper
• Soluble FMS-like tyrosine kinase-1 (sFlt-1) and serum placental growth factor (PlGF) as biomarkers for ectopic pregnancy and missed abortion.

  2011cited by this paper
• B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

  2010cited by this paper
• Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions.

  2008cited by this paper
• APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells.

  2008cited by this paper
• Expression of BAFF in the trophoblast and decidua of normal early pregnant women and patients with recurrent spontaneous miscarriage.

  2008cited by this paper
• Different degrees of vascularization and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues.

  2007cited by this paper
• APRIL-Deficient Mice Have Normal Immune System Development

  2004cited by this paper
• Impaired IgA class switching in APRIL-deficient mice.

  2004cited by this paper
• Conception to ongoing pregnancy: the 'black box' of early pregnancy loss.

  2002cited by this paper
• BLyS and APRIL Form Biologically Active Heterotrimers That Are Expressed in Patients with Systemic Immune-Based Rheumatic Diseases1

  2002cited by this paper
• APRIL modulates B and T cell immunity.

  2002cited by this paper
• Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases.

  2001cited by this paper
• BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

  2001cited by this paper
• Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI.

  2000cited by this paper
• APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity

  2000cited by this paper
• BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth

  1999cited by this paper
• BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.

  1999cited by this paper
• Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome.

  1996cited by this paper
• Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies.

  1996cited by this paper
• Pregnancy: Comparison of colour Doppler features and pathological findings in complicated early pregnancy

  1994cited by this paper
• Histological study of the materno-embryonic interface in spontaneous abortion.

  1990cited by this paper
• Frequency of chromosomal abnormalities in miscarriages and perinatal deaths.

  1977cited by this paper

• Serum BAFF levels in pregnant patients with systemic lupus erythematosus.

  2026cites this paper
• Research Progress in Predictions of Miscarriage

  2025cites this paper
• Biochemical markers for prediction of the first half pregnancy losses: a review

  2024influential citation
• BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth

  2023cites this paper
• Maternal and cord blood BAFF and APRIL levels during pregnancy

  2022cites this paper
• B-Cells and BAFF in Primary Antiphospholipid Syndrome, Targets for Therapy?

  2022cites this paper