A bird’s eye view of the dynamics of pancreatic β‐cell heterogeneity

Heterogeneity across pancreatic β-cells is well known and there is growing appreciation that sub-populations of islet β-cells exist as transcriptionally (and functionally) distinct groups. Here, we discuss current evidence on heterogeneity and provide a model to recognise how β-cells might function together as a mini-organ, over a lifetime. Being mindful of these possibilities would aid in developing strategies to prevent, treat, or manage functional β-cell loss in diabetes.

• Publication year

  2021

• Venue

  Acta Physiologica

• Publication date

  2021-04-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/apha.13664PMID 33884752
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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