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Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease

O. Dasa,Steven M. Smith,G. Howard,R. Cooper-DeHoff,Y. Gong,E. Handberg,C. Pepine

Published 2021 in JAMA Network Open

ABSTRACT

Key Points Question Is short-term blood pressure variability from one physician office visit to the next (hereafter referred to as visit-to-visit blood pressure variability) associated with increased long-term mortality risk? Findings In this cohort study, 16 688 patients with hypertension who were 50 years of age or older with coronary artery disease were followed up for a mean of 10.9 years. When comparing quintiles of systolic blood pressure variability measures, higher quintiles were associated with long-term mortality even after adjusting for baseline demographic characteristics, mean blood pressure, and comorbidities; the signal was stronger in women compared with men. Meaning These findings support efforts to identify and minimize visit-to-visit blood pressure variability to potentially reduce excess mortality later in life.

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