Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist

SUMMARY: This article will familiarize neuroradiologists with the pathophysiology, clinical findings, and standard MR imaging and PET imaging features of multiple forms of dementia as well as new emerging techniques. Cases were compiled from multiple institutions with the goal of improved diagnostic accuracy and improved patient care as well as information about biomarkers on the horizon. Dementia topics addressed include the following: Alzheimer disease, frontotemporal dementia, cerebral amyloid angiopathy, Lewy body dementia, Parkinson disease and Parkinson disease variants, amyotrophic lateral sclerosis, multisystem atrophy, Huntington disease vascular dementia, and Creutzfeldt-Jakob disease.

• Publication year

  2021

• Venue

  American Journal of Neuroradiology

• Publication date

  2021-04-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.3174/ajnr.A7079PMID 33926896PMCID PMC8191669
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

  2020cited by this paper
• Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

  2020cited by this paper
• Brain iron deposition is linked with cognitive severity in Parkinson’s disease

  2020cited by this paper
• Dementia spectrum disorders: lessons learnt from decades with PET research

  2019influential reference
• Association between white matter lesions and the cerebral glucose metabolism in patients with cognitive impairment.

  2019cited by this paper
• Current radiotracers to image neurodegenerative diseases

  2019influential reference
• Association between white matter lesions and cerebral glucose metabolism in patients with cognitive impairment

  2019cited by this paper
• Clinical significance of amyloid β positivity in patients with probable cerebral amyloid angiopathy markers

  2019cited by this paper
• Regional structural hypo‐ and hyperconnectivity of frontal–striatal and frontal–thalamic pathways in behavioral variant frontotemporal dementia

  2018cited by this paper
• PET/CT of Dementia.

  2018cited by this paper
• 18F-FDG PET for Prediction of Conversion to Alzheimer’s Disease Dementia in People with Mild Cognitive Impairment: An Updated Systematic Review of Test Accuracy

  2018cited by this paper
• Molecular imaging in dementia: Past, present, and future

  2018cited by this paper
• The Role of Brain Magnetic Resonance Imaging (MRI) as an Early Detector of Cognitive Impairment

  2018cited by this paper
• White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

  2018influential reference
• Clinical imaging in dementia with Lewy bodies

  2018cited by this paper
• Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia: a meta-analysis

  2018cited by this paper
• Clinical utility of FDG-PET in amyotrophic lateral sclerosis and Huntington’s disease

  2018cited by this paper
• Huntington's disease: a clinical review

  2018cited by this paper
• Imaging and Molecular Mechanisms of Alzheimer’s Disease: A Review

  2018influential reference
• Cognitive Impairment and Dementias.

  2018cited by this paper
• Reader response: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB consortium

  2018cited by this paper
• The glymphatic pathway in neurological disorders.

  2018cited by this paper
• Magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment

  2018cited by this paper
• MRI of the Swallow Tail Sign: A Useful Marker in the Diagnosis of Lewy Body Dementia?

  2017influential reference
• Amyloid positron emission tomography in sporadic cerebral amyloid angiopathy: A systematic critical update

  2017cited by this paper
• Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?

  2017cited by this paper
• Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity.

  2017cited by this paper
• Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment

  2017cited by this paper
• Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits

  2017cited by this paper
• Amyloid-PET burden and regional distribution in cerebral amyloid angiopathy: a systematic review and meta-analysis of biomarker performance

  2017cited by this paper
• Diagnosis and management of dementia with Lewy bodies

  2017cited by this paper
• 18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

  2017cited by this paper
• Frontotemporal Dementia.

  2017cited by this paper
• Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease

  2017cited by this paper
• Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.

  2016cited by this paper
• Multimodality Review of Amyloid-related Diseases of the Central Nervous System.

  2016cited by this paper
• Diagnostic accuracy of (18)F amyloid PET tracers for the diagnosis of Alzheimer's disease

  2016cited by this paper
• Neural plasticity and behavior – sixty years of conceptual advances

  2016cited by this paper
• Current status of PET imaging in Huntington’s disease

  2016cited by this paper
• Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury.

  2016cited by this paper
• Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

  2016cited by this paper
• Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

  2016cited by this paper
• Role of neuroimaging in multidisciplinary approach towards Non-Alzheimer’s dementia

  2015cited by this paper
• Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

  2015cited by this paper
• Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta‐analysis of 75 fMRI studies

  2015cited by this paper
• The Role of Neuroimaging in Evaluating Patients Affected by Creutzfeldt–Jakob Disease: A Systematic Review of the Literature

  2015cited by this paper
• PET imaging in neurology: Alzheimer's and Parkinson's diseases.

  2015cited by this paper
• Incidence of cerebral microbleeds in preclinical Alzheimer disease

  2014cited by this paper
• Brain PET in suspected dementia: patterns of altered FDG metabolism.

  2014cited by this paper
• In vivo tau imaging: Obstacles and progress

  2014cited by this paper
• Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer’s disease

  2013influential reference
• Florbetapir (F18‐AV‐45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging

  2013cited by this paper
• Brain imaging in the study of Alzheimer's disease

  2012influential reference
• National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

  2012cited by this paper
• Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

  2012cited by this paper
• Cerebral microbleeds and vascular cognitive impairment.

  2010cited by this paper
• Frequent amyloid deposition without significant cognitive impairment among the elderly.

  2008cited by this paper
• Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study.

  2007cited by this paper
• Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study.

  2004cited by this paper
• Region-Specific Decline of Cerebral Glucose Metabolism in Patients with Frontotemporal Dementia: A Prospective 18F-FDG-PET Study

  2004cited by this paper
• Brain magnetic resonance imaging in multiple-system atrophy and Parkinson disease: a diagnostic algorithm.

  2002influential reference
• Frontotemporal dementia

  1999cited by this paper
• Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease

  1998cited by this paper
• The metabolic anatomy of Parkinson's disease: Complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies

  1990cited by this paper
• NeuroImage: Clinical Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?

  year unknowninfluential reference
• NeuroImage: Clinical

  year unknowncited by this paper

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  2026cites this paper
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  2026cites this paper
• Reducing inference cost of Alzheimer’s disease identification using an uncertainty-aware ensemble of uni-modal and multi-modal learners

  2025cites this paper
• From morphology to single-cell molecules: high-resolution 3D histology in biomedicine

  2025cites this paper
• The role of nuclear medicine in neurodegenerative diseases: a narrative review.

  2025cites this paper
• Dementia-related adverse events associated with direct oral anticoagulants use: a real-world, pharmacovigilance study based on the FAERS database.

  2025cites this paper
• The future of Alzheimer’s disease risk prediction: a systematic review

  2025cites this paper
• AlzStack: Forecasting early-onset Alzheimer's with an explainable AI system using multiple data balancing techniques

  2025cites this paper
• Multi-modal approaches to Alzheimer's disease diagnosis: Combining cognitive assessments with biomarkers and imaging

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• Clinical Translation of Integrated PET‐MRI for Neurodegenerative Disease

  2025cites this paper
• Ethical dilemmas and medicolegal implications of nuclear medicine imaging in dementias

  2025cites this paper
• ACR Appropriateness Criteria® Dementia: 2024 Update.

  2025cites this paper
• Comparative Diagnostic Performance of Amyloid‐β Positron Emission Tomography and Magnetic Resonance Imaging in Alzheimer's Disease: A Head‐to‐Head Meta‐Analysis

  2024cites this paper
• A hybrid multimodal machine learning model for Detecting Alzheimer's disease

  2024cites this paper
• Evaluation of Neurodegenerative Disorders with Amyloid-β, Tau, and Dopaminergic PET Imaging: Interpretation Pitfalls

  2024cites this paper
• [Comparative characteristics of neuropsychological and neurometabolic changes in patients with Alzheimer's disease and vascular cognitive impairment].

  2024cites this paper
• The use of an anterior-posterior atrophy index to distinguish Alzheimer's disease from frontotemporal disorders: an automated volumetric MRI Study

  2024cites this paper
• Association of the Area Deprivation Index With Dementia Basic Workup and Diagnosis in Central and Western Virginia

  2024cites this paper
• Comparative Characteristics of Neuropsychological and Neurometabolic Parameters in Patients with Alzheimer’s Disease and Vascular Cognitive Impairment

  2024cites this paper
• Performance of plasma p‐tau217 and NfL in an unselected memory clinic setting

  2024cites this paper
• Hybrid PET/MRI with Flutemetamol and FDG in Alzheimer's Disease Clinical Continuum.

  2023cites this paper
• The role of magnetic resonance imaging in the diagnosis and prognosis of dementia

  2022influential citation
• Interpretable brain disease classification and relevance-guided deep learning

  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper