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HYPOLIPIDEMIC AND ANTI-OXIDATIVE ACTIVITIES OF TERMINALIA ARJUNA BARKS AGAINST INDUCED HYPERLIPIDEMIC ALBINO RATS

Shahrokh Mojarradgandoukmolla,Nadir M. Nanakali,Ahmed Ab.Jabbar

Published 2021 in Plant Archives

ABSTRACT

One of the preeminent factors of Coronary heart disease contemplated to be Hyperlipidemia. High cholesterol additives activates hyperlipidemia and Oxidative stress in rats eliciting biochemical and toxicological changes. Traditionally, Terminalia arjuna bark consumed as medicinal agents for various purposes, mainly as cardiac protectives. The present data experiments the influences of Terminalia arjuna ethanolic extract in chow(5% cholesterol+0.5% cholic acid) induced hyperlipidemia rats in compare with free plant additive control group rats. The hyperlipidemia aftermath assessed by evaluating the lipid profile and oxidative stress biomarkers. The test results showed that the Terminalia arjuna bark possessed significant cutback of the cholesterol level, Low density lipoprotein and elevated High density lipoprotein in Hyperlipidemia model rats. Free radicals cut off capabilities of T. arjuna has observed by significantly decreased levels of Malondialdehyde and Superoxide dismutase in induced hyperlipidemia rats. The blood inquiry of all tested groups revealed non-significant alteration by T. arjuna bark extract. The ethanolic extract of Terminalia arjuna bark (500 mg/kg body weight) possessed positive effect on the lipid profile and could serve as good antioxidant agent incorporating into Certain recipes as edible materials hyperlipidemia and high oxidative stress patients as they rely on chemical drugs drugs for too many periods.

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