Morphology‐based mammalian stem cell tests reveal potential developmental toxicity of donepezil

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular Reproduction and Development

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mrd.22423PMID 25269881
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Manipulating The Mouse Embryo A Laboratory Manual

  2016influential reference
• Robbins and Cotran pathologic basis of disease

  2015cited by this paper
• Generation of Aggregates of Mouse ES Cells that Show Symmetry Breaking, Polarisation and Emergent Collective Behaviour in vitro

  2014cited by this paper
• Current acetylcholinesterase-inhibitors: a neuroinformatics perspective.

  2014cited by this paper
• Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction.

  2013cited by this paper
• A review on cholinesterase inhibitors for Alzheimer’s disease

  2013cited by this paper
• Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output.

  2013cited by this paper
• The DNT-EST: a predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro.

  2013cited by this paper
• They See a Rat, We Seek a Cure for Diseases: The Current Status of Animal Experimentation in Medical Practice

  2013cited by this paper
• Regulation of developmental competence and commitment towards the definitive endoderm lineage in human embryonic stem cells.

  2013cited by this paper
• High‐Dose Donepezil (23 mg/day) for the Treatment of Moderate and Severe Alzheimer's Disease: Drug Profile and Clinical Guidelines

  2013cited by this paper
• Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells

  2012cited by this paper
• Embryonic stem cell test: stem cell use in predicting developmental cardiotoxicity and osteotoxicity.

  2012cited by this paper
• Higher-Dose (23 mg/day) Donepezil Formulation for the Treatment of Patients with Moderate-to-Severe Alzheimer's Disease

  2012cited by this paper
• Retinoic acid signalling during development

  2012cited by this paper
• Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo.

  2012cited by this paper
• Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain

  2012influential reference
• Neural Tube Closure in Mouse Whole Embryo Culture

  2011cited by this paper
• Donepezil, Anti-Alzheimer's Disease Drug, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice

  2011cited by this paper
• Thalidomide: the tragedy of birth defects and the effective treatment of disease.

  2011cited by this paper
• Present state and future perspectives of using pluripotent stem cells in toxicology research

  2011cited by this paper
• Comprar Langman's Medical Embryology (International Edition) | T. W. Sadler | 9781451144611 | Lippincott Williams & Wilkins

  2011cited by this paper
• The method of rodent whole embryo culture using the rotator-type bottle culture system.

  2010cited by this paper
• Whole embryo culture: a "New" technique that enabled decades of mechanistic discoveries.

  2010cited by this paper
• Hox genes and regional patterning of the vertebrate body plan.

  2010cited by this paper
• Differential Axial Requirements for Lunatic Fringe and Hes7 Transcription during Mouse Somitogenesis

  2009cited by this paper
• Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure

  2009cited by this paper
• Hox genes and vertebrate axial pattern.

  2009cited by this paper
• Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension.

  2009cited by this paper
• Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

  2009cited by this paper
• Pluripotent stem cell lines.

  2008cited by this paper
• Larsen's Human Embryology

  2008influential reference
• A ROCK inhibitor permits survival of dissociated human embryonic stem cells

  2007cited by this paper
• New cell lines from mouse epiblast share defining features with human embryonic stem cells

  2007cited by this paper
• Derivation of pluripotent epiblast stem cells from mammalian embryos

  2007cited by this paper
• Animal testing: is it worth it?

  2007cited by this paper
• Wnt/beta-catenin signaling and body plan formation in mouse embryos.

  2006cited by this paper
• Human embryo and early fetus research

  2006cited by this paper
• Use of murine embryonic stem cells in embryotoxicity assays: the embryonic stem cell test.

  2006cited by this paper
• Whole embryo culture: an important tool in developmental toxicology today.

  2006cited by this paper
• Wnt/β-catenin signaling and body plan formation in mouse embryos

  2006cited by this paper
• Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome.

  2005cited by this paper
• Retinoic Acid Controls the Bilateral Symmetry of Somite Formation in the Mouse Embryo

  2005cited by this paper
• The future of teratology research is in vitro

  2005influential reference
• History, Research Ethics

  2004cited by this paper
• Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents).

  2004cited by this paper
• Cdx2 is essential for axial elongation in mouse development.

  2004cited by this paper
• Where is the evidence that animal research benefits humans?

  2004cited by this paper
• Human embryonic stem cells: prospects for development

  2004cited by this paper
• Missing evidence that animal research benefits humans

  2004cited by this paper
• Human embryonic stem cells as a model for early human development.

  2004cited by this paper
• Donepezil for vascular cognitive impairment.

  2004cited by this paper
• Cholinesterase Inhibitors Used in the Treatment of Alzheimer’s Disease

  2004cited by this paper
• Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.

  2003cited by this paper
• Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension.

  2003cited by this paper
• Alzheimer disease in the US population: prevalence estimates using the 2000 census.

  2003cited by this paper
• Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation.

  2003cited by this paper
• Twenty one years of P19 cells: what an embryonal carcinoma cell line taught us about cardiomyocyte differentiation.

  2003cited by this paper
• The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites

  2003cited by this paper
• Experimenting with Humans and Animals: From Galen to Animal Rights

  2003cited by this paper
• Cholinesterase inhibitors for the treatment of Alzheimer's disease:: getting on and staying on.

  2003cited by this paper
• Teratogenicity of Recently Introduced Medications in Human Pregnancy

  2002cited by this paper
• The role of vitamin A in mammalian reproduction and embryonic development.

  2002cited by this paper
• Stem Cells from the Mammalian Blastocyst

  2001cited by this paper
• Successful Use of Donepezil for the Treatment of Dementia with Lewy Bodies

  2001cited by this paper
• A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease

  2001cited by this paper
• Chronic Donepezil Treatment Is Associated with Slowed Cognitive Decline in Alzheimer’s Disease

  2001cited by this paper
• The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

  2001cited by this paper
• The pharmacology of donepezil: a new treatment of Alzheimer's disease.

  1999cited by this paper
• T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.

  1999cited by this paper
• Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

  1999influential reference
• Requirement for Wnt3 in vertebrate axis formation

  1999cited by this paper
• Brachyury (T) expression in embryonal carcinoma P19 cells resembles its expression in primitive streak and tail‐bud but not that in notochord

  1999cited by this paper
• Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.

  1998cited by this paper
• Embryonic stem cell lines derived from human blastocysts.

  1998cited by this paper
• Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6

  1998cited by this paper
• The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo.

  1997cited by this paper
• Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.

  1997cited by this paper
• Maintenance of somite borders in mice requires the Delta homologue Dll1

  1997cited by this paper
• A review of the contribution of whole embryo culture to the determination of hazard and risk in teratogenicity testing.

  1997cited by this paper
• Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.

  1996cited by this paper
• Regulation of Acetylcholinesterase Expression during Neuronal Differentiation (*)

  1996cited by this paper
• Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.

  1996cited by this paper
• Notch1 is required for the coordinate segmentation of somites.

  1995cited by this paper
• Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos.

  1994cited by this paper
• Wnt-3a regulates somite and tailbud formation in the mouse embryo.

  1994cited by this paper
• P19 embryonal carcinoma cells.

  1993cited by this paper
• Langman's Medical Embryology

  1991cited by this paper
• The History of the Use of Animals in Research and the Development of the Animal Welfare Concept

  1987cited by this paper
• The developmental potential of a euploid male teratocarcinoma cell line after blastocyst injection.

  1982cited by this paper
• WHOLE‐EMBRYO CULTURE AND THE STUDY OF MAMMALIAN EMBRYOS DURING ORGANOGENESIS

  1978cited by this paper
• Langman's Medical Embryology

  1969cited by this paper

• Embryotoxicity analysis of anti-arrhythmia drugs amiodarone, dronedarone, and their metabolites using 3D gastruloid models.

  2025cites this paper
• Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays.

  2025cites this paper
• Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure list.

  2024cites this paper
• FGTN: Fragment-based graph transformer network for predicting reproductive toxicity

  2024cites this paper
• Nr6a1 controls axially-restricted body elongation, segmentation, patterning and lineage allocation

  2022influential citation
• Developmental toxicity of remdesivir, an anti‐COVID‐19 drug, is implicated by in vitro assays using morphogenetic embryoid bodies of mouse and human pluripotent stem cells

  2022influential citation
• Gastruloids: A Novel System for Disease Modelling and Drug Testing

  2022cites this paper
• Toward better assessments of developmental toxicity using stem cell‐based in vitro embryogenesis models

  2022cites this paper
• Thin fluorinated polymer film microcavity arrays for 3D cell culture and label-free automated feature extraction.

  2021cites this paper
• Dolutegravir impairs stem cell-based 3D morphogenesis models in a manner dependent on dose and timing of exposure: an implication for its developmental toxicity.

  2021cites this paper
• Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae.

  2020cites this paper
• A New Microengineered Platform for 4D Tracking of Single Cells in a Stem‐Cell‐Based In Vitro Morphogenesis Model

  2020cites this paper
• Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling-dependent manner.

  2020cites this paper
• Exploring the binding mode of donepezil with calf thymus DNA by spectroscopic and molecular docking methods.

  2020cites this paper
• Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells.

  2019cites this paper
• Use of stem cells as alternative methods to animal experimentation in predictive toxicology.

  2019cites this paper
• RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner

  2018cites this paper
• Risk Assessment Using Human Pluripotent Stem Cells: Recent Advances in Developmental Toxicity Screens

  2018cites this paper
• Stem-Cell-Based In vitro Morphogenesis Models to Investigate Developmental Toxicity of Chemical Exposures

  2018cites this paper
• Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant

  2018cites this paper
• Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans‐resveratrol

  2018cites this paper
• Developmental toxicity assessment of common excipients using a stem cell-based in vitro morphogenesis model.

  2017cites this paper
• Exposure‐Based Validation of an In Vitro Gastrulation Model for Developmental Toxicity Assays

  2017cites this paper
• Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals

  2016cites this paper
• Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling.

  2016cites this paper
• Use of In Vitro Morphogenesis of Mouse Embryoid Bodies to Assess Developmental Toxicity of Therapeutic Drugs Contraindicated in Pregnancy.

  2016cites this paper
• An in vitro gastrulation model recapitulates the morphogenetic impact of pharmacological inhibitors of developmental signaling pathways

  2015cites this paper