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The comparison of curcumin and nanocurcumin effects on the expression of E6 and E7 human papilloma virus oncogenes and P53 and pRb factors in HeLa and fibroblast cell lines

Rezvaneh Vahedian Sadeghi,M. Parsania,M. Sadeghizadeh,S. Haghighat,S. M. Farsani

Published 2021 in Unknown venue

ABSTRACT

Cervical cancer is a common cancer in women around the world. Human papillomavirus infection is main cause of this cancer. Currently treatment methods include chemotherapy, radiation therapy and surgery. These methods usually cause severe reactions and drug resistance in the patients, so finding a safe natural drug for treatment can be very helpful. Curcumin is a compound derived from the root of the Curcuma longa plant and is the active ingredient in a food spice. Various studies have confirmed the anti-cancer, chemoprotective and genes and proteins regulatory effects of this component. Insolubility, low cellular uptake and low bioavailability are common limitations of curcumin use. To overcome these limitations, a nano-formulation of curcumin has been developed in our laboratory. In this study, the effect of nanocurcumin on cellular apoptosis induction of Hela cancer cells was compared with curcumin. It has demonstrated that nanocurcumin function is three time more effective than curcumin in same concentration. This nano-formulation of curcumin in 15µM concentration was able to reduce the expression of E6 and E7 oncogenes, and increase P53 and Rb tumor suppressors in HeLa cancerous cells with p-value = 0.001 − 0.0001, whereas curcumin altered these genes expression in 50µM concentration with p-value = 0.05 − 0.01. Nanocurcumin has no significant effect on the viability of normal fibroblast cells. Therefore, this compound has no effect on normal cells. These findings are consistent with the results of previous studies about nanocurcurcumin in other types of cancer. Therefore, nanocurcumin may be a suitable option to consider for cervical cancer treatment.

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