NMR-based substrate analog docking to Escherichia coli peptidyl-tRNA hydrolase.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Molecular Biology

• Publication date

  2011-09-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jmb.2011.06.025PMID 21718701
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Solution structure and dynamics of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis H37Rv.

  2008cited by this paper
• Recycling of ribosomal complexes stalled at the step of elongation in Escherichia coli.

  2008cited by this paper
• A practical synthesis of 2′-aminoacylamino-2′-deoxyadenosines

  2007cited by this paper
• Ribosome Recycling Factor and Release Factor 3 Action Promotes TnaC-Peptidyl-tRNA Dropoff and Relieves Ribosome Stalling during Tryptophan Induction of tna Operon Expression in Escherichia coli

  2007cited by this paper
• Structural plasticity and enzyme action: crystal structures of mycobacterium tuberculosis peptidyl-tRNA hydrolase.

  2007cited by this paper
• Characterization of peptidyl-tRNA hydrolase encoded by open reading frame Rv1014c of Mycobacterium tuberculosis H37Rv

  2007cited by this paper
• Information-driven protein–DNA docking using HADDOCK: it is a matter of flexibility

  2006cited by this paper
• Identification in Archaea of a Novel D-Tyr-tRNATyr Deacylase*

  2006cited by this paper
• Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis.

  2006cited by this paper
• Initiator tRNA binding by e/aIF5B, the eukaryotic/archaeal homologue of bacterial initiation factor IF2.

  2005cited by this paper
• Structural analysis of the group II intron splicing factor CRS2 yields insights into its protein and RNA interaction surfaces.

  2005cited by this paper
• Essential role of histidine 20 in the catalytic mechanism of Escherichia coli peptidyl-tRNA hydrolase.

  2004cited by this paper
• A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.

  2004cited by this paper
• Genes required for mycobacterial growth defined by high density mutagenesis

  2003cited by this paper
• HADDOCK: a protein-protein docking approach based on biochemical or biophysical information.

  2003cited by this paper
• Peptidyl-tRNA hydrolase from Sulfolobus solfataricus.

  2003cited by this paper
• Peptidyl‐tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable

  2002cited by this paper
• Orthologs of a novel archaeal and of the bacterial peptidyl–tRNA hydrolase are nonessential in yeast

  2002cited by this paper
• Specific interaction between the ribosome recycling factor and the elongation factor G from Mycobacterium tuberculosis mediates peptidyl‐tRNA release and ribosome recycling in Escherichia coli

  2001cited by this paper
• Functional Characterization of thed-Tyr-tRNATyr Deacylase from Escherichia coli *

  1999cited by this paper
• Receptor site for the 5'-phosphate of elongator tRNAs governs substrate selection by peptidyl-tRNA hydrolase.

  1999cited by this paper
• Synthesis of 3'-azido- and 3'-amino-3'-deoxyadenosine in both enantiomeric forms

  1998cited by this paper
• Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl‐tRNA from the ribosome

  1998cited by this paper
• Initiation factors IF1 and IF2 synergistically remove peptidyl-tRNAs with short polypeptides from the P-site of translating Escherichia coli ribosomes.

  1998cited by this paper
• Crystal structure at 1.2 Å resolution and active site mapping of Escherichia coli peptidyl‐tRNA hydrolase

  1997cited by this paper
• 1H, 13C and 15N chemical shift referencing in biomolecular NMR

  1995cited by this paper
• MC-Fit: using Monte-Carlo methods to get accurate confidence limits on enzyme parameters

  1994cited by this paper
• Role of the 1-72 base pair in tRNAs for the activity of Escherichia coli peptidyl-tRNA hydrolase.

  1993cited by this paper
• Tests of the ribosome editor hypothesis

  1987cited by this paper
• Transacylation rates of (aminoacyl)adenosine moiety at the 3'-terminus of aminoacyl transfer ribonucleic acid.

  1983cited by this paper
• Accumulation of peptidyl tRNA is lethal to Escherichia coli

  1979cited by this paper
• The influence of the peptide chain length on the activity of peptidyl-tRNA hydrolase from E. coli.

  1975cited by this paper
• Proceedings: Role of the peptide moiety in the interaction between peptidyl-tRNA and peptidyl-tRNA hydrolase.

  1975cited by this paper
• The specificity of peptidyl‐tRNA hydrolase from E. coli

  1975cited by this paper
• Mutant E. coli strain with temperature sensitive peptidyl-transfer RNA hydrolase.

  1972cited by this paper
• Enzymatic hydrolysis of N‐substituted aminoacyl‐tRNA

  1968cited by this paper
• Studies on polynucleotides. LXXXVI. Enzymic hydrolysis of N-acylaminoacyl-transfer RNA.

  1968cited by this paper
• Enzymatic hydrolysis of N-substituted aminoacyl-tRNA.

  1967cited by this paper

• Binding mode between peptidyl-tRNA hydrolase and the peptidyl-A76 moiety of the substrate

  2025cites this paper
• In Silico Screening and Molecular Dynamics Simulations of Small Molecules Targeting Peptidyl tRNA Hydrolase for Drug-Resistant Tuberculosis

  2025cites this paper
• Characterization of structure of peptidyl-tRNA hydrolase from Enterococcus faecium and its inhibition by a pyrrolinone compound.

  2024cites this paper
• Rationally designed pooled CRISPRi-seq uncovers an inhibitor of bacterial peptidyl-tRNA hydrolase.

  2024cites this paper
• Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential

  2024cites this paper
• Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase

  2024cites this paper
• A comparative analysis of tRNA[superscript Ala] production

  2022cites this paper
• Natural Product Inhibition and Enzyme Kinetics Related to Phylogenetic Characterization for Bacterial Peptidyl-tRNA Hydrolase 1

  2021cites this paper
• Structural and functional characterization of peptidyl-tRNA hydrolase from Klebsiella pneumoniae.

  2020cites this paper
• Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies.

  2020cites this paper
• Role of methionine 71 in substrate recognition and structural integrity of bacterial peptidyl-tRNA hydrolase.

  2018cites this paper
• High‐resolution crystal structure of peptidyl‐tRNA hydrolase from Thermus thermophilus

  2018cites this paper
• Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase

  2017influential citation
• Bacterial production of site specific 13C labeled phenylalanine and methodology for high level incorporation into bacterially expressed recombinant proteins

  2017cites this paper
• Expedited isolation of natural product peptidyl-tRNA hydrolase inhibitors from a Pth1 affinity column

  2017cites this paper
• Bacterial production of site specific 13C labeled phenylalanine and methodology for high level incorporation into bacterially expressed recombinant proteins

  2016cites this paper
• Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1

  2016cites this paper
• Expression, purification, and solubility optimization of peptidyl-tRNA hydrolase 1 from Bacillus cereus.

  2014cites this paper
• Structural and functional insights into peptidyl-tRNA hydrolase.

  2014cites this paper
• Small Molecule Binding, Docking, and Characterization of the Interaction between Pth1 and Peptidyl-tRNA

  2013cites this paper
• Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8.

  2013cites this paper
• Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase

  2012influential citation
• RNA-binding Site of Escherichia coli Peptidyl-tRNA Hydrolase

  2011cites this paper