cIAP1/2 antagonization by SMAC mimetic induces non‐canonical NF‐κB mediated TH17 cell homotypic interactions and increases their resistance to shear stress

T helper-17 (TH17) cells express the transcription factor RORγt, produce IL-17 and IL-22, and are required for defense against extracellular pathogens and to sustain the integrity of epithelial barrier surfaces [1]. However, unrestrained TH17 cell responses have been implicated in autoimmune disease pathogenesis [2, 3]. A network of transcription factors control TH17 differentiation, including RORγt [4] and members of the NF-κB family [5]. The canonical NF-κB pathway is necessary to initiate T cell activation [6], while noncanonical NF-κB is critical for balancing TH lineage decisions [7]. Activation of the non-canonical NF-κB pathway depends on the stabilization of NF-κB inducing Kinase (NIK), which is regulated by the E3 ubiquitin ligases cIAP1 and cIAP2 [8].

• Publication year

  2021

• Venue

  European Journal of Immunology

• Publication date

  2021-05-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.202048983PMID 33960415
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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