Xenotransplantation of neonatal porcine bone marrow‐derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis

The clinical utility of stem cell therapy for peripheral artery disease has not been fully discussed, and one obstacle is limited donor supplies. In this study, we attempted to rescue mouse ischemic hind limb by xenotransplantation of neonatal porcine bone marrow‐derived mesenchymal stem cells (npBM‐MSCs).

• Publication year

  2021

• Venue

  Xenotransplantation

• Publication date

  2021-05-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/xen.12693PMID 33960029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long‐term follow‐up for the microbiological safety of clinical microencapsulated neonatal porcine islet transplantation

  2020cited by this paper
• Development and characterization of novel clinical grade neonatal porcine bone marrow‐derived mesenchymal stem cells

  2019cited by this paper
• Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway

  2019cited by this paper
• Autologous stem cell therapy for peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials

  2019cited by this paper
• Update regarding xenotransplantation in Japan

  2019cited by this paper
• Cost and Scalability Analysis of Porcine Islet Isolation for Islet Transplantation: Comparison of Juvenile, Neonatal and Adult Pigs

  2019cited by this paper
• VEGF-C induced by TGF- β1 signaling in gastric cancer enhances tumor-induced lymphangiogenesis

  2019cited by this paper
• Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials

  2018cited by this paper
• 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed b

  2018cited by this paper
• Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

  2018cited by this paper
• Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1.

  2018cited by this paper
• Critical limb ischemia: current challenges and future prospects

  2018cited by this paper
• Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

  2017cited by this paper
• 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

  2017cited by this paper
• Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases , in collaboration with the European Society for Vascular Surgery ( ESVS ) – Web Addenda

  2017cited by this paper
• Wytyczne ESC dotyczące rozpoznawania i leczenia chorób tętnic obwodowych w 2017 roku, przygotowane we współpracy z ESVS

  2017cited by this paper
• Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community

  2017cited by this paper
• 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease

  2016cited by this paper
• Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes

  2016cited by this paper
• Current status and future of clinical islet xenotransplantation

  2016cited by this paper
• CCL5 promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-507 in human chondrosarcoma cells

  2016cited by this paper
• Human mesenchymal stem cells - current trends and future prospective

  2015cited by this paper
• Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use is associated with reduced major adverse cardiovascular events among patients with critical limb ischemia

  2015cited by this paper
• CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture.

  2015cited by this paper
• The chemokine system in innate immunity.

  2015cited by this paper
• Regulatory aspects of clinical xenotransplantation.

  2015cited by this paper
• Peritoneal VEGF-A expression is regulated by TGF-β1 through an ID1 pathway in women with endometriosis

  2015cited by this paper
• GM-CSF Treated F4/80+ BMCs Improve Murine Hind Limb Ischemia Similar to M-CSF Differentiated Macrophages

  2014cited by this paper
• Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis.

  2014cited by this paper
• Mesenchymal Stem Cells as a Treatment for Peripheral Arterial Disease: Current Status and Potential Impact of Type II Diabetes on Their Therapeutic Efficacy

  2013cited by this paper
• Vascular endothelial growth factor-C derived from CD11b+ cells induces therapeutic improvements in a murine model of hind limb ischemia.

  2013cited by this paper
• A review on CXCR4/CXCL12 axis in oncology: no place to hide.

  2013cited by this paper
• Bone marrow derived mesenchymal stem cells from aged mice have reduced wound healing, angiogenesis, proliferation and anti‐apoptosis capabilities

  2012cited by this paper
• Human versus porcine mesenchymal stromal cells: phenotype, differentiation potential, immunomodulation and cardiac improvement after transplantation

  2012cited by this paper
• Aging Effect on Neurotrophic Activity of Human Mesenchymal Stem Cells

  2012cited by this paper
• Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential

  2012cited by this paper
• Treatment of peripheral arterial disease using stem and progenitor cell therapy.

  2011cited by this paper
• 2011 ACCF/AHA Focused Update of the Guideline for the Management of patients with peripheral artery disease (Updating the 2005 Guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.

  2011cited by this paper
• The Effect of Age on the Efficacy of Human Mesenchymal Stem Cell Transplantation after a Myocardial Infarction

  2010cited by this paper
• Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

  2006cited by this paper
• The morbidity and mortality following a diagnosis of peripheral arterial disease: Long-term follow-up of a large database

  2005cited by this paper
• Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.

  2005cited by this paper
• Role of VEGF-C and VEGF-D in lymphangiogenesis in gastric cancer

  2005cited by this paper
• Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood.

  2005cited by this paper
• Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy

  2005cited by this paper
• Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial.

  2005cited by this paper
• Transplantation of pig stem cells into rat brain: proliferation during the first 8 weeks.

  2004cited by this paper
• Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis.

  2004cited by this paper
• Productive infection of human primary cells and cell lines with porcine endogenous retroviruses.

  2001cited by this paper
• Vascular-specific growth factors and blood vessel formation

  2000cited by this paper
• Management of peripheral arterial disease (PAD). TransAtlantic Inter-Society Consensus (TASC). Section D: chronic critical limb ischaemia.

  2000cited by this paper
• Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC).

  2000cited by this paper
• Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

  1998cited by this paper
• Infection of human cells by an endogenous retrovirus of pigs

  1997cited by this paper
• In Japan …

  1975cited by this paper

• The effect of bone marrow derived cell therapies on hind limb perfusion, A systematic review and meta-analysis.

  2024cites this paper
• Establishment of a Simple, Reproducible, and Long-lasting Hind Limb Animal Model of Lymphedema

  2023cites this paper
• Development and characterization of islet‐derived mesenchymal stem cells from clinical grade neonatal porcine cryopreserved islets

  2023cites this paper
• Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2

  2023cites this paper
• Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis

  2022cites this paper
• Lymphangiogenesis, a potential treatment target for myocardial injury.

  2022cites this paper
• The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease

  2022cites this paper
• Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells

  2021cites this paper