Effect of supraphysiological estrogen levels on arterial stiffness and hemodynamic parameters.

OBJECTIVE The present study evaluates the arterial stiffness and hemodynamic parameters in patients with a supraphysiological estrogen level due to in vitro fertilization (IVF) with controlled ovarian hyperstimulation (COH). METHODS A total of 82 female patients aged 24-45 years were included. Their arterial stiffness parameters were analyzed before and after the appropriate COH protocol involving arteriography using Mobil-O-Graph NG (IEM GmbH, Stolberg, Germany) 24-hour ambulatory blood pressure monitor. RESULTS Systolic, diastolic, mean, central systolic, and diastolic blood pressures, as well as peripheral vascular resistance, were significantly lower after COH therapy (p=0.001, 0.002, <0.001, <0.001, 0.040, and <0.001, respectively). In contrast, there was no statistically significant difference observed in heart rate, pulse pressure, or cardiac output. The pulse wave velocity measurement was significantly lower after COH than the baseline levels [5.3 m/s (4.5-6.9 m/s) versus 5.4 m/s (4.7-7.3 m/s,); p<0.001], but the augmentation index was not significantly different [28% (4%-41%) versus 29% (5%-43%); p=0.090]. When the patients were grouped according to the occurrence of a pregnancy after IVF therapy, all parameters were not different between the pregnancy (+) and pregnancy (-) patients (p>0.05). CONCLUSION Arterial stiffness and hemodynamic parameters significantly decreased in IVF patients who underwent COH therapy. The long-term clinical significance of this short-term effect should be investigated with prospective studies. There was no significant difference in all parameters before and after COH when the pregnancy (+) and pregnancy (-) patients were compared.

• Publication year

  2021

• Venue

  Anatolian journal of cardiology

• Publication date

  2021-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.14744/anatoljcardiol.2020.38890PMID 33960310PMCID PMC8114636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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