Vaccines for COVID-19 - state of the art

Abstract Vaccine candidates against COVID-19 have diverse compositions, from traditional inac-tivated virus vaccines to various new-generation vaccines. Currently, approximately 175 research teams worldwide are studying various vaccine possibilities as the necessityto vacci-nate the entire population against the SARS-CoV-2 virus is urgent. Although, the development of a safe and effective COVID-19 vaccine is not easy, the manufacturing, distribution, and administration of the vaccine can also face extraordinary challenges. In this review, we enhance some of the current knowledge regarding the clinical trial phases on different COVID-19 vaccine candidates, its potential strengths and disadvantages, and to discuss ethical aspects and their chances of success in large-scale applications.

• Publication year

  2021

• Venue

  Unknown venue

• Publication date

  2021-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1590/1806-9304202100S100002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Is COVID-19 receiving ADE from other coronaviruses?

  2020cited by this paper
• Developing Covid-19 Vaccines at Pandemic Speed.

  2020cited by this paper
• Ensuring global access to COVID-19 vaccines

  2020cited by this paper
• SARS-CoV-2 Vaccines: Status Report

  2020cited by this paper
• The COVID-19 vaccine development landscape

  2020cited by this paper
• Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development

  2020cited by this paper
• A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains

  2020cited by this paper
• Developing a vaccine for covid-19

  2020cited by this paper
• Global efforts on vaccines for COVID-19: Since, sooner or later, we all will catch the coronavirus

  2020cited by this paper
• Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

  2020cited by this paper
• Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

  2020cited by this paper
• The early landscape of coronavirus disease 2019 vaccine development in the UK and rest of the world

  2020cited by this paper
• Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report

  2020cited by this paper
• BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

  2020cited by this paper
• An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

  2020cited by this paper
• The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

  2020cited by this paper
• Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.

  2020cited by this paper
• Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques

  2020cited by this paper
• Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials.

  2020cited by this paper
• Regulatory Decision-making on COVID-19 Vaccines During a Public Health Emergency.

  2020cited by this paper
• Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

  2020cited by this paper
• Frontiers in the COVID-19 vaccines development

  2020cited by this paper
• SARS-CoV-2 vaccines in development

  2020cited by this paper

• Vaccination with Two Doses of AstraZeneca® (ChAdOx1-S) and Pfizer® (BNT162b2) Induces the Production of Immunoglobulin G for COVID-19 Without Damaging Hematological, Biochemical, Inflammatory and Oxidative Biomarkers

  2026cites this paper
• COVID-19: death profile in patients in southwest Paraná / COVID-19: perfil do óbito em pacientes do sudoeste do Paraná

  2025cites this paper
• Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles

  2025cites this paper
• Impacto de medidas não farmacológicas contra a COVID-19

  2025cites this paper
• ADAPTAÇÃO DE MICRO E PEQUENAS EMPRESAS DO SETOR GASTRONÔMICO DURANTE A PANDEMIA DA COVID-19: UM ESTUDO DE CASO NO MUNICÍPIO DE CAÇADOR, SANTA CATARINA

  2024cites this paper
• Healthcare professionals’ hand hygiene: perspectives of nursing student’s in patients/relatives role

  2024cites this paper
• COVID-19 in prisons: validity of a knowledge, attitude and practice survey

  2024cites this paper
• Modeling factors affecting the design and manufacture of the recombinant vaccine: Key points for health policymakers and professionals

  2024cites this paper
• VACCINE ADHERENCE AND ADVERSE EVENTS OF THE SARS-COV VACCINE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.

  2024cites this paper
• Headache as the most prevalent post-vaccination adverse event after Covid-19 vaccination

  2024cites this paper
• ALTERAÇÕES HEMATOLÓGICAS E BIOQUÍMICAS EM PACIENTES DIAGNOSTICADOS COM COVID-19

  2023cites this paper
• Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19

  2023cites this paper
• Inquérito online sobre os motivos para hesitação vacinal contra a COVID-19 em crianças e adolescentes do Brasil

  2023cites this paper
• Exercícios Físicos durante a Pandemia da COVID-19: do negativismo ao resgate das práticas protetivas

  2023cites this paper
• ANÁLISE DO PERFIL VACINAL CONTRA À COVID-19 DA CIDADE DE CARUARU-PE

  2023cites this paper
• AVALIAÇÃO DE EVENTOS ADVERSOS DAS VACINAS CONTRA COVID-19 NA POPULAÇÃO DE UM MUNICÍPIO DO NORTE DE MINAS GERAIS

  2023cites this paper
• COVID-19 nas prisões: validação de um inquérito de conhecimento, atitude e prática

  2023cites this paper
• Covid-19: processo de trabalho da equipe de enfermagem em Unidade de Terapia Intensiva

  2023cites this paper
• Pandemic impacts in Natal, one of the main tourist destinations in Brazil

  2022cites this paper
• Epidemiological Monitoring of COVID-19 in a Brazilian City: The Interface between the Economic Policies, Commercial Behavior, and Pandemic Control

  2022cites this paper
• COVID-19 VACCINE DRIVERS

  2022cites this paper
• Decisão de gestantes à vacinação contra Covid-19: protocolo de revisão de escopo

  2022cites this paper
• CHALLENGES AND STRATEGIES FOR VACCINATION AGAINST COVID-19

  2022cites this paper
• Negacionismo na pandemia de COVID-19

  2022cites this paper
• The impact of Covid-19 pandemic over the dental patients

  2021cites this paper
• Vacinas de mRNA contra a Covid-19: aberta uma nova janela no campo da imunologia

  2021cites this paper
• Vacinas contra Coronavírus (COVID-19; SARS-COV-2) no Brasil: um panorama geral

  2021cites this paper
• New variants of SARS-CoV-2, vaccine immune response and the Brazilian reality

  2021cites this paper
• Analysis of adverse effects caused by mRNA vaccines used in the fight against COVID-19

  2021cites this paper
• Terapias medicamentosas empregadas no tratamento da Covid-19 no Brasil: revisão bibliográfica narrativa

  2021cites this paper
• Optimization and qualification of vaccination records against Covid-19 in public health: the case of "e-SUS Vacinação"

  2021cites this paper
• Estudo prospectivo de patentes relacionadas a vacinas contra o SARS-CoV-2

  2021cites this paper
• EDUCATIONAL BOOKLET FOR THE PROMOTION OF IMMUNIZATION AGAINST COVID-19: CONSTRUCTION AND VALIDATION

  year unknowncites this paper
• Myocardial Injury and Prognosis in Hospitalized COVID-19 Patients in Brazil: Results From The Brazilian COVID-19 Registry

  year unknowncites this paper