Bacterial Biofilms and Implant Infections: A Perspective

Nosocomial infections in the form of bacterial biofilms on medical implants continue to pose a significant challenge for medical professionals in its treatment. This review addresses the basic biofilm formation process and illustrates in detail its manifestation in causing chronic infections. Bacterial biofilms are described as a microbial consortium attached to a substratum by exopolymeric substances. Biofilms trap soluble organic compounds and act as a sink for nutrients as well as inorganic compounds. They immobilize extracellular enzymes and DNA, to propagate the microbial colony on implant surfaces, and manifest the disease. Frequently, the persistent chronic infections arise due to biofilm formation on the implanted devices and cause severe inconvenience to the patients. These infections are difficult to eradicate and require a strong antibiotics course, which can penetrate the biofilm to control, however, in some cases it warrants the removal of the implanted device. Finally, this review highlights recent advances in antimicrobial compounds that aid in preventing implant infections.

• Publication year

  2020

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.33696/ORTHOPAEDICS.1.016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Tolerance and Persistence of Pseudomonas aeruginosa in Biofilms Exposed to Antibiotics: Molecular Mechanisms, Antibiotic Strategies and Therapeutic Perspectives

  2020cited by this paper
• Inorganic-organic Nanomaterials for Therapeutics and Molecular Imaging Applications

  2020cited by this paper
• Intravital Multiphoton Examination of Implant-Associated Staphylococcus aureus Biofilm Infection

  2020cited by this paper
• Comparative assessment of exopolymer production and chemical characteristics of two environmental biofilm isolates of Pseudomonas aeruginosa

  2020cited by this paper
• Toxicity of Biologically Active Peptides and Future Safety Aspects: An Update.

  2018cited by this paper
• Antimicrobial Peptides against Microbial Biofilms: their Structures and Modes of Action

  2017cited by this paper
• Present and future medical applications of microbial exopolysaccharides

  2015cited by this paper
• Calcium-Mediated Modulation of Staphylococcal Bacterial Biofilms

  2014cited by this paper
• From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

  2013cited by this paper
• Bacteria-surface interactions.

  2013cited by this paper
• Dispersal of Bap-mediated Staphylococcus aureus biofilm by proteinase K

  2012cited by this paper
• Microbial Biofilms

  2011cited by this paper
• New Trends in Diagnosis and Control Strategies for Implant Infections

  2011cited by this paper
• Bacterial adhesion: From mechanism to control

  2010cited by this paper
• Persister cells.

  2010influential reference
• Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms.

  2010cited by this paper
• Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.

  2007cited by this paper
• The role of small-colony variants in failure to diagnose and treat biofilm infections in orthopedics

  2007cited by this paper
• Cyclic Dimeric GMP Signaling and Regulation of Surface-Associated Developmental Programs

  2007cited by this paper
• Bacterially speaking.

  2006cited by this paper
• Survival strategies of infectious biofilms.

  2005cited by this paper
• Role of Capsular Colanic Acid in Adhesion of Uropathogenic Escherichia coli

  2003cited by this paper
• Detection of Differential Gene Expression in Biofilm-Forming versus Planktonic Populations of Staphylococcus aureus Using Micro-Representational-Difference Analysis

  2001cited by this paper
• Mechanisms of biofilm resistance to antimicrobial agents.

  2001cited by this paper
• Effect of Subinhibitory Antibiotic Concentrations on Polysaccharide Intercellular Adhesin Expression in Biofilm-Forming Staphylococcus epidermidis

  2000cited by this paper
• Heterogeneity in biofilms.

  2000cited by this paper
• INFLUENCE OF FLOW ON ORDERING CHARACTERISTICS OF A BACTERIAL BIOFILM

  1997cited by this paper

• Evaluating antimicrobial efficacy in medical devices: The critical role of simulating in use test conditions.

  2025cites this paper
• Systematic review of metal-based alloys with autogenous antibacterial capability

  2025cites this paper
• Targeted Drug Delivery Strategies in Overcoming Antimicrobial Resistance: Advances and Future Directions

  2025cites this paper
• Pharmaceutical applications of chitosan on medical implants: A viable alternative for construction of new biomaterials?

  2024cites this paper
• Sequestration of cobalt and nickel by biofilm forming bacteria isolated from spent nuclear fuel pool water

  2023cites this paper
• Mono and bilayer coatings of alkanethiol and silane on copper: Prevents corrosion and regulate bacterial adhesion

  2023cites this paper