Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models

The crude ethanol extract (EEOH) of the bark of Maytenus rigida Mart (Celastraceae) a plant used in Brazil herbal traditional medicine, was tested for anti-inflammatory, antiulcer and antidiarrhoeal activities in animal models. No acute toxicological sign was observed in animals treated with the highest dose (5000 mg/kg, p.o. or 2000 mg/kg i.p.) of EEOH. The extract doses of 250, 500 or 750 mg/kg revealed a significant inhibitory effect (P < 0,01) in carrageenin-induced rat paw oedema and exhibited ulcer-protective properties against ethanol-induced ulceration in rats. An anti-diarrhoeal activity (P < 0.01) was also observed in castor-oil-induced diarrhoeal in mice. The intestinal transit was significantly (P < 0.01) reduced, however the pretreatment did not reduce the weight of intestinal contents. These results support the popular applications of Maytenus rigida for the treatment of inflammation, ulcer and diarrhoea in Brazil herbal traditional medicine.

• Publication year

  2007

• Venue

  Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy

• Publication date

  2007-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1590/S0102-695X2007000300006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Antimicrobial activity of some medicinal barks used in Peruvian Amazon.

  2007cited by this paper
• Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil

  2007cited by this paper
• Antioxidant activity of Maytenus ilicifolia root bark.

  2006cited by this paper
• Medicinal plants and other botanical products from the Brazilian Official Pharmacopoeia

  2006cited by this paper
• Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat.

  2006cited by this paper
• Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark.

  2006cited by this paper
• Avaliação da atividade antiulcerogênica da Maytenus truncata Reiss (Celastraceae)

  2005cited by this paper
• L-carnitine inhibits ethanol-induced gastric mucosal injury in rats.

  2005cited by this paper
• STUDIES ON THE MECHANISMS OF

  2005cited by this paper
• Anatomia foliar de Maytenus Mol. emend Mol. (Celastraceae), ocorrente no Estado do Rio de Janeiro, Brasil

  2005cited by this paper
• Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia.

  2004cited by this paper
• A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa

  2004cited by this paper
• Morfoanatomia de folhas de Maytenus rigida Mart. (Celastraceae); uma especie utilizada como medicinal no nordeste do Brasil

  2004cited by this paper
• DNA polymerase beta lyase inhibitors from Maytenus putterlickoides.

  2004cited by this paper
• Evaluation of the anti-ulcerogenic activity of a dry extract of Maytenus ilicifolia Martius ex. Reiss produced by a jet spouted bed dryer.

  2003cited by this paper
• Antiulcerogenic and analgesic effects of the Austroplenckia populnea extracts in mice

  2002cited by this paper
• Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.

  2001cited by this paper
• Up‐regulation of cyclooxygenase‐1 and ‐2 in human gastric ulcer

  2001cited by this paper
• Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia.

  2001cited by this paper
• Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli.

  2001cited by this paper
• Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.

  2000cited by this paper
• New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line.

  1999cited by this paper
• Gastrointestinal drugs.

  1998cited by this paper
• Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa.

  1997cited by this paper
• Castor oil: an update on mechanism of action

  1996cited by this paper
• Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum

  1996cited by this paper
• Nitric oxide and castor oil-induced diarrhea.

  1994cited by this paper
• Dissociation of castor oil‐induced diarrhoea and intestinal mucosal injury in rat: effect of NG‐nitro‐L‐arginine methyl ester

  1994cited by this paper
• Antidiarrhoeic Activity of Euphorbia hirta Extract and Isolation of an Active Flavonoid Constituent

  1993cited by this paper
• Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenesis and new therapeutic strategies

  1992cited by this paper
• Time Course of PAF Formation by Gastrointestinal Tissue in Rats After Castor Oil Challenge

  1992cited by this paper
• PAF formation by human gastrointestinal mucosa/submucosa in‐vitro: release by ricinoleic acid, and inhibition by 5‐aminosalicylic acid

  1992cited by this paper
• Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine.

  1991cited by this paper
• Antiulcerogenic effects of two Maytenus species in laboratory animals.

  1991cited by this paper
• Studies on the mechanism of ethanol-induced gastric damage in rats.

  1988cited by this paper
• Laxatives and the production of autacoids by rat colon

  1986cited by this paper
• Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection.

  1984cited by this paper
• HISTAMINE H2‐ANTAGONISTS MODIFY GASTRIC EMPTYING IN THE RAT

  1982cited by this paper
• Pharmacological modulation of edema mediated by prostaglandin, serotonin and histamine

  1980cited by this paper
• Distention ulcer as a model for testing of drugs for ulcerogenic side effects

  1978cited by this paper
• Laxatives: an update on mechanism of action.

  1978cited by this paper
• Stimulation of adenylate cyclase in homogenates of isolated intestinal epithelial cells from hamsters. Effects of gastrointestinal hormones, prostaglandins, and deoxycholic and ricinoleic acids.

  1978cited by this paper
• Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis

  1978cited by this paper

• Defect-enhanced visible-light photocatalysis in α–Fe2O3 nanoparticles synthesized via a maytenus rigida-assisted Sol-Gel method

  2025cites this paper
• Capture of the radical 2,2-diphenyl-1-picryl-hydrazil by Maytenus rigida Mart 2,2-diphenyl-1-picryl-hydrazyl capture by Maytenus rigida Mart

  2020cites this paper
• Photoprotective property and cytotoxicity of polar extracts of three species of Maytenus native to the Southwest of Bahia

  2020cites this paper
• Anti-Inflammatory and Neurobehavioral Effects of the Leaves from Maytenus macrocarpa (Ruiz and Pavon) Briquet in Mice

  2019cites this paper
• Anti-mycobacterial, -oxidative, -proliferative and -inflammatory activities of dichloromethane leaf extracts of Gymnosporia senegalensis (Lam.) Loes

  2018cites this paper
• The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders

  2018cites this paper
• Maytenus distichophylla and Salacia crassifolia: source of products with potential acetylcholinesterase inhibition

  2017cites this paper
• Pharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases

  2017cites this paper
• Maytenus erythroxylon Reissek (Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms

  2017cites this paper
• Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts.

  2017cites this paper
• Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol.

  2017cites this paper
• harmacological potential of Maytenus species and isolated onstituents , especially tingenone , for treatment of painful nflammatory diseases

  2017cites this paper
• aytenus distichophylla and Salacia crassifolia : source of products with otential acetylcholinesterase inhibition

  2017cites this paper
• New neolignan glycoside and an unusual benzoyl malic acid derivative from Maytenus senegalensis leaves

  2015influential citation
• Tontelea micrantha ( Celastraceae-Hippocrateoideae )

  2015cites this paper
• Avaliação in vivo do potencial mutagênico e antimutagênico do extrato etanólico da entrecasca do caule de Maytenus rigida Mart. pelo teste de micronúcleo em sangue periférico de camundongos

  2014influential citation
• Evaluation of the central analgesic activity of the leaves of Maytenus macrocarpa (Ruiz & Pav.) Briq. (chuchuhuasi)

  2014cites this paper
• Efecto de Maytenus macrocarpa “Chuchuhuasi” en el sistema reproductor masculino del ratón (Mus musculus)

  2014cites this paper
• Structure, histochemistry and phytochemical profile of the bark of the sobol and aerial stem of Tontelea micrantha (Celastraceae - Hippocrateoideae).

  2014cites this paper
• Evaluation of anti-diarrheic properties of the aqueous methanolic extract of Palisota hirsuta leaves and its fractions using in vivo models

  2014cites this paper
• Equine gastric ulcer syndrome: risk factors and therapeutic aspects

  2014cites this paper
• Celastráceas: Fontes de Triterpenos Pentacíclicos com Potencial Atividade Biológica

  2014cites this paper
• Celastraceae Family: Source of Pentacyclic Triterpenes with Potential Biological Activity

  2014cites this paper
• Pharmacological interactions from the leaves of Maytenus macrocarpa "chuchuhuasi" with inhibitory and stimulating bowel motility drugs

  2013cites this paper
• Algistatic effect of a quinonamethide triterpene on Microcystis novacekii

  2013cites this paper
• RESEARCH ARTICLE ANTI-DIARRHEIC PROPERTIES OF THE AQUEOUS METHANOLIC EXTRACT OF PALISOTA HIRSUTA LEAVES AND ITS FRACTIONS IN MICE

  2013cites this paper
• Use of extracts of sunflower-seed oil (Helianthus annus L.) for the treatment of cutaneous injuries in equine metatarsus: a case report

  2012cites this paper
• Antigiardial activity of the hexane extract of Maytenus gonoclada mart.

  2012cites this paper
• Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

  2012cites this paper
• New Triterpenes from Maytenus robusta: Structural Elucidation Based on NMR Experimental Data and Theoretical Calculations

  2012cites this paper
• Analgesic and Antidiarrheal Properties of the Latex of Calotropis Procera

  2011cites this paper
• Maytenus heterophylla and Maytenus senegalensis, two traditional herbal medicines

  2011cites this paper
• Resilience and adaptation in the use of medicinal plants with suspected anti-inflammatory activity in the Brazilian Northeast.

  2011cites this paper
• Database Survey of Anti-Inflammatory Plants in South America: A Review

  2011cites this paper
• In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts

  2011cites this paper
• esilience and adaptation in the use of medicinal plants with suspected nti-inflammatory activity in the Brazilian Northeast ashington

  2011cites this paper
• Caracterização do gene ERG11 envolvido na resistência de Cryptococcus neoformans e Cryptococcus gatti as drogas azólicas e identificação de novos alvos a partir de produtos naturais

  2011cites this paper
• Avaliação da atividade antimicrobiana de Maytenus rigida Mart. (Celastraceae)

  2011cites this paper
• Avaliação da atividade antimicrobiana de Maytenus rigida Mart. (Celastraceae)

  2011cites this paper
• Avaliação da atividade cicatrizante do extrato etanólico da casca da Maytenus rigida Mart. (Celastracea)

  2010cites this paper
• Biological activity of Herissantia crispa (L.) Brizicky

  2009cites this paper
• Antioxidant activity of Maytenus imbricata Mart., Celastraceae

  2009cites this paper
• Patents of drugs extracted from Brazilian medicinal plants

  2009cites this paper
• Anti-diarrhoeal and CNS Depressant Activity of Methanolic Extract of Saccharum spontaneum Linn.

  2009cites this paper
• Evaluation of the toxicity and antiulcerogenic activity of the ethanol extract of Maytenus obtusifolia Mart. leaves

  2008cites this paper
• Antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba

  2008cites this paper