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Caramel dye IV increases hepatic and renal oxidative stress injuries

Emerson Marins,J. S. D. Silva,Aline Zuanazzi Pasinato,Pamela C. Da Rosa,V. A. Oliveira,Joana Grandó Moretto,José Eduardo Vargas,F. Soares,R. Barcelos

Published 2020 in Integrative Food Nutrition and Metabolism

ABSTRACT

Caramel dye IV (C-IV) is a synthetic organic product, does not present nutritional, ergogenic, or technological factors, but leads to reactive oxygen species (ROS). This way may lead to damage to a wide range of molecules, leading to cancer, cardiovascular, and neurodegenerative diseases development. We aimed to verify the effects of different doses of C-IV dye on the markers of oxidative stress in the liver and kidneys from male Swiss CF-1 mice, divided into four experimental groups: control; C-IV 0.3 g/kg; C-IV 1 g/kg and C-IV 3 g/kg. We found that mainly 3 g/Kg of C-IV dye promote oxidative damage in liver and kidney homogenates, evidenced by the increase of lipid peroxidation, reduction of free SH groups, and higher ROS production. As a consequence, increased superoxide dismutase, catalase, and acetylcholinesterase enzyme activities were detected, as a response to the increased oxidative stress production. These damages were confirmed through histology images. Since the mice dose used in this study is 30-fold lower than the human daily dose consumption, these results indicate that the daily doses might induce substantial oxidative stress damages and possibly lead to chronic disease development.

PUBLICATION RECORD

  • Publication year

    2020

  • Venue

    Integrative Food Nutrition and Metabolism

  • Publication date

    Unknown publication date

  • Fields of study

    Medicine, Chemistry, Environmental Science

  • Identifiers
    DOI 10.15761/IFNM.1000282
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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