Ebola, Dengue, Chikungunya, and Zika Infections in Neonates and Infants.

Emerging infectious diseases, including Ebola, chikungunya, Zika, and dengue, may have significant impacts on maternal-fetal dyads and neonatal outcomes. Pregnant women infected with Ebola demonstrate high mortality and very low evidence of neonatal survival. Maternal chikungunya infection can result in high rates of perinatal transmission, and infected neonates demonstrate variable disease severity. Dengue can be transmitted to neonates via vertical transmission or perinatal transmission. Zika is characterized by mild disease in pregnant women, but congenital infection can be severe. Treatment largely is supportive for these diseases, and vaccine development remains under way, with promising recent advances, notably for Ebola.

• Publication year

  2021

• Venue

  Clinics of Perinatology

• Publication date

  2021-06-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.clp.2021.03.006PMID 34030816
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

  2020cited by this paper
• Recent successes in therapeutics for Ebola virus disease: no time for complacency

  2020cited by this paper
• The Global Expansion of Dengue: How Aedes aegypti Mosquitoes Enabled the First Pandemic Arbovirus.

  2020cited by this paper
• Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age

  2020cited by this paper
• Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

  2020cited by this paper
• Ebola virus disease

  2020cited by this paper
• Safety and immunogenicity of a Zika purified inactivated virus vaccine given via standard, accelerated, or shortened schedules: a single-centre, double-blind, sequential-group, randomised, placebo-controlled, phase 1 trial.

  2020cited by this paper
• Pregnancy and breastfeeding in the context of Ebola: a systematic review.

  2020cited by this paper
• Chikungunya in Infants and Children: Is Pathogenesis Increasing?

  2019cited by this paper
• Recent Progress in Vaccine Development Against Chikungunya Virus

  2019cited by this paper
• Zika Vaccine Development: Current Status

  2019cited by this paper
• Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.

  2019cited by this paper
• Dengue, Zika and chikungunya during pregnancy: pre- and post-travel advice and clinical management

  2019cited by this paper
• Zika Virus Infection - After the Pandemic.

  2019cited by this paper
• Are we Missing Neonatal Dengue?

  2019cited by this paper
• Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil

  2019cited by this paper
• The current and future global distribution and population at risk of dengue

  2019cited by this paper
• Dengue vaccination during pregnancy - An overview of clinical trials data.

  2018cited by this paper
• Maternal, Fetal, and Neonatal Outcomes in Pregnant Dengue Patients in Mexico

  2018cited by this paper
• The neurological complications of chikungunya virus: A systematic review

  2018cited by this paper
• A prospective matched study on symptomatic dengue in pregnancy

  2018cited by this paper
• Symptomatic Dengue during Pregnancy and Congenital Neurologic Malformations

  2018cited by this paper
• Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

  2018cited by this paper
• Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas

  2018cited by this paper
• Congenital Zika Syndrome and Extra-Central Nervous System Detection of Zika Virus in a Pre-term Newborn in Mexico

  2018cited by this paper
• Estimating the Risk of Vertical Transmission of Dengue: A Prospective Study.

  2018cited by this paper
• Arboviruses and pregnancy: maternal, fetal, and neonatal effects.

  2017cited by this paper
• Symptomatic dengue infection during pregnancy and livebirth outcomes in Brazil, 2007-13: a retrospective observational cohort study.

  2017cited by this paper
• Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings

  2017cited by this paper
• Global Epidemiology of Dengue Outbreaks in 1990–2015: A Systematic Review and Meta-Analysis

  2017cited by this paper
• First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

  2017cited by this paper
• Investigation on prenatal dengue infections in a dengue outbreak in Guangzhou City, China

  2017cited by this paper
• Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy

  2017cited by this paper
• Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

  2017cited by this paper
• Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

  2017cited by this paper
• Estimated Incubation Period for Zika Virus Disease

  2017cited by this paper
• Zika Virus

  2016cited by this paper
• Zika Virus Infection in Pregnant Women in Rio de Janeiro.

  2016cited by this paper
• Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study.

  2016cited by this paper
• Congenital and perinatal complications of chikungunya fever: a Latin American experience.

  2016cited by this paper
• Zika virus damages the human placental barrier and presents marked fetal neurotropism

  2016cited by this paper
• Dengue during pregnancy and adverse fetal outcomes: a systematic review and meta-analysis.

  2016cited by this paper
• Live neonates born to mothers with Ebola virus disease: a review of the literature

  2016cited by this paper
• Zika Virus Infection in Pregnant Women in Rio de Janeiro — Preliminary Report

  2016cited by this paper
• Delivery of an Ebola Virus-Positive Stillborn Infant in a Rural Community Health Center, Sierra Leone, 2015.

  2016cited by this paper
• A Pregnant Patient With Ebola Virus Disease

  2015cited by this paper
• Congenital Chikungunya Virus Infection in Sincelejo, Colombia: A Case Series.

  2015cited by this paper
• [Analysis of clinical characteristics of the 12 cases of neonatal dengue fever in Guangzhou in 2014 and literatures review].

  2015cited by this paper
• Ebola Virus Disease Outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and Symptoms, Management and Outcomes

  2015cited by this paper
• Chikungunya virus and the global spread of a mosquito-borne disease.

  2015cited by this paper
• Dilemmas in Managing Pregnant Women With Ebola: 2 Case Reports

  2015cited by this paper
• Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial.

  2015cited by this paper
• Shedding of Ebola Virus in an Asymptomatic Pregnant Woman.

  2015cited by this paper
• Neurocognitive Outcome of Children Exposed to Perinatal Mother-to-Child Chikungunya Virus Infection: The CHIMERE Cohort Study on Reunion Island

  2014cited by this paper
• What Obstetrician–Gynecologists Should Know About Ebola: A Perspective From the Centers for Disease Control and Prevention

  2014cited by this paper
• Pregnancy and infection.

  2014cited by this paper
• Management of pregnant women infected with Ebola virus in a treatment centre in Guinea, June 2014.

  2014cited by this paper
• Ebola virus disease in West Africa--clinical manifestations and management.

  2014cited by this paper
• Epidemiology of dengue: past, present and future prospects

  2013cited by this paper
• Perinatal transmission of dengue: a report of 7 cases.

  2013cited by this paper
• The global distribution and burden of dengue

  2013cited by this paper
• Ebola haemorrhagic fever.

  2011cited by this paper
• Recurrent Shoulder Dystocia: A Review

  2010cited by this paper
• Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006

  2010cited by this paper
• Dengue Infection in Pregnancy: Prevalence, Vertical Transmission, and Pregnancy Outcome

  2008cited by this paper
• Dengue Virus Infection in Late Pregnancy and Transmission to the Infants

  2008cited by this paper
• Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La Réunion

  2008cited by this paper
• Mother-to-Child Transmission of Chikungunya Virus Infection

  2007cited by this paper
• [Chikungunya infection in pregnancy: Evidence for intrauterine infection in pregnant women and vertical transmission in the parturient. Survey of the Reunion Island outbreak].

  2006cited by this paper
• Infection à Chikungunya chez la femme enceinte et risque de transmission materno-fœtale: Étude dans un contexte d’épidémie en 2005-2006 à l’île de la Réunion

  2006cited by this paper
• [Early maternal-fetal transmission of the Chikungunya virus].

  2006cited by this paper
• Vertical Dengue Infection: Case Reports and Review

  2004cited by this paper
• Vertical transmission of dengue: first case report from Bangladesh.

  2003cited by this paper
• Ebola Hemorrhagic Fever Transmission and Risk Factors of Contacts, Uganda

  2003cited by this paper
• [Dengue fever and pregnancy. A study of 38 cases in french Guiana].

  2000cited by this paper
• Filoviridae: Marburg and Ebola viruses.

  2000cited by this paper
• Ebola hemorrhagic fever and pregnancy.

  1999cited by this paper
• Dengue and dengue haemorrhagic fever.

  1998cited by this paper
• Vertical transmission of dengue.

  1997cited by this paper
• Ebola haemorrhagic fever in Zaire, 1976.

  1978cited by this paper

• Access to licenced vaccines for high-threat infectious diseases: a scoping review and interpretive analysis of Ebola virus disease

  2026cites this paper
• Mimickers of Hypoxic Ischemic Encephalopathy.

  2025cites this paper
• The identification of a blood circular RNA signature that differentiates Chikungunya virus infection

  2025cites this paper
• [Expert consensus on the diagnosis, treatment, and prevention of neonatal dengue, chikungunya, and Zika virus infections (2025)].

  2025cites this paper
• Severe neonatal dengue with confirmed vertical transmission of DENV-3: A fatal case from Honduras

  2025influential citation
• Perinatal outcomes of symptomatic chikungunya, dengue and Zika infection during pregnancy in Brazil: a registry-based cohort study

  2025influential citation
• 基孔肯雅病毒的母婴传播及其对新生儿神经系统的影响

  2025cites this paper
• Neurodevelopmental Outcomes in Children Vertically Exposed to Chikungunya Virus: A Two Years Follow-up Study

  2024cites this paper
• Radiological and Imaging Evidence in the Diagnosis and Management of Microbial Infections: An Update

  2023cites this paper
• Neurodevelopmental outcomes in congenital and perinatal infections

  2023cites this paper
• Developing brain under renewed attack: viral infection during pregnancy

  2023cites this paper
• Vaccine value profile for Chikungunya

  2023cites this paper
• Detection of Potential Arbovirus Infections and Pregnancy Complications in Pregnant Women in Jamaica Using a Smartphone App (ZIKApp): Pilot Evaluation Study

  2022cites this paper
• Development and characterization of an inducible assay system to measure Zika virus capsid interactions

  2022cites this paper
• Metagenomic Next-generation Sequencing: Application in Infectious Diseases

  2021cites this paper
• Prevention of Emerging Infections in Children

  2021cites this paper
• The ZIKApp for detection of potential arbovirus infections and pregnancy complications in pregnant women in Jamaica: a pilot study (Preprint)

  2021cites this paper