Current knowledge about the connection between health status and gut microbiota from birth to elderly. A narrative review.

The human body is colonized from the birth by a large number of microorganisms. This will constitute a real "functional microbial organ" that is fundamental for homeostasis and therefore for health in humans. Those microorganisms. The microbial populations that colonize humans creating a specific ecosystem they have been collectively referred to as "human microbiota" or "human normal microflora". The microbiota play an important pathophysiological role in the various locations of the human body. This article focuses on one of the most important, that is the enteric microbiota. The composition (quantitative and qualitative) of microbes is analyzed in relation to age and environment during the course of human life. It also highlights eubiosis and dysbiosis as key terms for its role in health and disease. Finally, it analyzes its bi-directional relationship with the microbiota of the lungs, skin and that of the brain, and consequently for the whole central and peripheral nervous system for the maintenance of health in the human body.

• Publication year

  2021

• Venue

  Frontiers in Bioscience

• Publication date

  2021-05-30

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.52586/4930PMID 34162042
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Gut microbiota and aging.

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• Probiotics Improve Urogenital Health in Women

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• Brain-Gut-Microbiota Axis and Mental Health

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• Rhinocerebral Mucormycosis with Orosinusal Involvement: Diagnostic and Surgical Treatment Guidelines.

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• Intervention strategies for cesarean section–induced alterations in the microbiota-gut-brain axis

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• Gut Microbiota-brain Axis

  2016cited by this paper
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  2016cited by this paper
• The Journal of Clinical Investigation

  2016cited by this paper
• Gut microbiota in autism and mood disorders.

  2016cited by this paper
• Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

  2016cited by this paper
• EVALUATION OF PROCALCITONIN, VITAMIN D AND C-REACTIVE PROTEIN LEVELS IN SEPTIC PATIENTS WITH POSITIVE EMOCOLTURES. OUR PRELIMINARY EXPERIENCE

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• Dysbiosis of the gut microbiota in disease

  2015cited by this paper
• Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome

  2015cited by this paper
• Regulation of lung immunity and host defense by the intestinal microbiota

  2015cited by this paper
• The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems

  2015cited by this paper
• Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota

  2015cited by this paper
• The gut microbiota in internal medicine: implications for health and disease.

  2015cited by this paper
• Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

  2015cited by this paper
• Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour.

  2015cited by this paper
• Epidemiology and risk factors for IBD

  2015cited by this paper
• Dysbiotic Events in Gut Microbiota: Impact on Human Health

  2014cited by this paper
• Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

  2013cited by this paper
• Gut metagenome in European women with normal, impaired and diabetic glucose control

  2013cited by this paper
• Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications.

  2013cited by this paper
• The role of intestinal microbiota and the immune system.

  2013influential reference
• Psychobiotics: a novel class of psychotropic.

  2013cited by this paper
• Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

  2012cited by this paper
• Gut microbiota composition correlates with diet and health in the elderly

  2012cited by this paper
• Functional interactions between the gut microbiota and host metabolism

  2012cited by this paper
• Genomic variation landscape of the human gut microbiome

  2012cited by this paper
• New insights into the impact of the intestinal microbiota on health and disease: a symposium report.

  2012cited by this paper
• Altered neuro-endocrine–immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model

  2012cited by this paper
• Reduced anxiety‐like behavior and central neurochemical change in germ‐free mice

  2011cited by this paper
• Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

  2011cited by this paper
• The endocannabinoid system links gut microbiota to adipogenesis

  2010cited by this paper
• The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat

  2010cited by this paper
• Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.

  2010cited by this paper
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  2009cited by this paper
• Human gut microbiota in obesity and after gastric bypass

  2009cited by this paper
• Principles and clinical implications of the brain–gut–enteric microbiota axis

  2009cited by this paper
• Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota: A Three-Way Crosstalk

  2008cited by this paper
• Helicobacter pylori infection and gastric MALTomas: an up-to-date and therapy highlight.

  2008cited by this paper
• Pathophysiological mechanisms of stress-induced intestinal damage.

  2008cited by this paper
• Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy

  2007cited by this paper
• Thromboembolic risk after knee endoprosthesis.

  2007cited by this paper
• Development of the Human Infant Intestinal Microbiota

  2007cited by this paper
• [Abdominal sepsis in surgical patients. Pathophysiology and prevention].

  2006cited by this paper
• Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy

  2006cited by this paper
• Stress and gut microbiota: Does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response?

  2006cited by this paper
• [Periodontitis and systemic diseases].

  2006cited by this paper
• [Treatment of bowel obstruction in our own experience].

  2005cited by this paper
• Tight junctions, leaky intestines, and pediatric diseases

  2005cited by this paper
• [Drug/food interactions: an actual therapeutic outcome].

  2004cited by this paper
• Regulation of short-chain fatty acid production

  2003cited by this paper
• [Expression of epithelial oncoproteins in large intestine neoplasms].

  2002cited by this paper
• [Argyrophilic nucleolar organizer regions (AgNORs) as malignancy biomarkers in colorectal neoplasms].

  2001cited by this paper
• [Role of mast cells in the physiopathology of gastric lesions caused by Helicobacter pylori].

  2000cited by this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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