Clinical practice guideline of BRCA1/2 testing for patients with breast cancer: Chinese Society of Breast Surgery (CSBrS) practice guideline 2021

F. Xie,Shu Wang

Published 2021 in Chinese Medical Journal

ABSTRACT

Breast cancer is the most common female cancer around the world. Approximately 5% to 10% of breast cancer is associated with a hereditary predisposition from inherited germline mutations, with about 15% of mutations occurring in the breast cancer susceptibility genes (BRCA1/2). Individuals carrying BRCA1/2 mutations may reduce their risk of breast cancer through screening and preventing managements. It is essential for breast oncologists to improve their ability of identifying individuals with high risk of BRCA1/2 mutations, providing reasonable genetic counselling guidance to high risk individuals. Chinese Society of Breast Surgery (CSBrS) evaluated the relevant evidences using the Grading of Recommendations Assessment, Development, and Evaluation system, and developed the Clinical Practice Guideline of BRCA1/2 Testing for Patients with Breast Cancer (Version 2021), with the aim of providing guidance to the clinical practices of breast surgeons in China.

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