Efficacy of 265-nm ultraviolet light in inactivating infectious SARS-CoV-2

Although, Low-pressure (LP) mercury lamps that emit wavelengths of around 254 nm have been widely applied as ultraviolet (UV) light devices for decontamination of microorganisms, they have raised environmental concerns due to their mercury content. Therefore, UV-LED lamps have high potential for practical use as a replacement for LP mercury lamps. In this study, we evaluated the efficacy of 265-nm UV irradiation in comparison to 254-nm and 280-nm UV irradiation for inactivating infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Irradiation from a 265-nm deep UV light-emitting diode (DUV-LED) lamp efficiently inactivated SARS-CoV-2 at a similar level as a 254-nm UV cold cathode lamp, and at a higher level than a 280-nm DUV-LED lamp.

• Publication year

  2021

• Venue

  Journal of photochemistry and photobiology

• Publication date

  2021-06-17

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.jpap.2021.100050PMID 34183999PMCID 8215571
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination

  2020cited by this paper
• Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation

  2020cited by this paper
• Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses

  2020cited by this paper
• Susceptibility of SARS-CoV-2 to UV irradiation

  2020influential reference
• Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

  2020cited by this paper
• Global transmission network of SARS-CoV-2: from outbreak to pandemic

  2020cited by this paper
• Applications of Light-Emitting Diodes (LEDs) in Food Processing and Water Treatment

  2020cited by this paper
• A new UV-LED device for automatic disinfection of stethoscope membranes.

  2015cited by this paper
• Quantum Yield of the Iodide–Iodate Chemical Actinometer: Dependence on Wavelength and Concentration¶

  2003cited by this paper
• Standardization of Methods for Fluence (UV Dose) Determination in Bench-Scale UV Experiments

  2003cited by this paper

• Up-conversion and vis-luminescent properties of Pr3+ ions in SiO2-СaF2 sol-gel nanoceramic

  2026cites this paper
• Development and Testing of a Portable Air Purifier with Chemical and UV-C Filtration for Virus and Pollutant Removal

  2025cites this paper
• Inactivation Challenges of SARS-CoV-2 on Surfaces in the Built Environment by Irradiation from Pulse Xenon, 275 nm Light-Emitting-Diode, and Far-Ultraviolet Sources.

  2025cites this paper
• Design and Implementation of Elevator Push-Buttons with Integrated Ultraviolet-C Light-Emitting Diode Light Sources for Disinfection

  2025cites this paper
• Development of Deep Ultraviolet LED Packaging

  2024cites this paper
• Estimation of Junction Temperature in Single 228 nm‐Band AlGaN Far‐Ultraviolet‐C Light‐Emitting Diode on c‐Sapphire Having 1.8 mW Power and 0.32% External Quantum Efficiency

  2024cites this paper
• Inactivation characteristics of a 280 nm Deep-UV irradiation dose on aerosolized SARS-CoV-2

  2023cites this paper
• Inactivation of Coronavirus OC43 by Excimer Lamp, UV Lamp, and Deep UV-LED at Irradiation Wavelengths of 222 nm, 254 nm, and 275 nm

  2023cites this paper
• Strain induced power enhancement of far-UVC LEDs on high temperature annealed AlN templates

  2023cites this paper
• Rapid inactivation of human respiratory RNA viruses by deep ultraviolet irradiation from light-emitting diodes on a high-temperature-annealed AlN/Sapphire template

  2023cites this paper
• Performance of a Pilot-Scale Continuous Flow Ozone-Based Hospital Wastewater Treatment System

  2023influential citation
• UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice

  2022cites this paper
• Comparison of the inactivation capacity of various UV wavelengths on SARS-CoV-2

  2022cites this paper
• UV and violet light can Neutralize SARS-CoV-2 Infectivity

  2022cites this paper
• Illuminating Human Norovirus: A Perspective on Disinfection of Water and Surfaces Using UVC, Norovirus Model Organisms, and Radiation Safety Considerations

  2022cites this paper
• Action Spectra of Bacteria and Purification of Pollutant Water at Faucets Using a Water Waveguide Method

  2022cites this paper
• DUV coherent light emission from ultracompact microcavity wavelength conversion device.

  2022cites this paper
• Milliwatt-power far-UVC AlGaN LEDs on sapphire substrates

  2022cites this paper
• SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix

  2022cites this paper
• UVC, UVB and UVA susceptibility of Phi6 and its suitability as a SARS-CoV-2 surrogate

  2022cites this paper
• Combating Coronavirus Using Resonant Electromagnetic Irradiation

  2022cites this paper
• A UVC LED Disinfection Closet for Reuse of Protective Coats

  2022cites this paper
• UVC radiation intensity dependence of pathogen decontamination rate: semiclassical theory and experiment

  2022cites this paper
• High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces

  2021cites this paper
• Clinical Application of Ultraviolet C Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 in Contaminated Hospital Environments

  2021cites this paper
• Review of air disinfection approaches and proposal for thermal inactivation of airborne viruses as a life-style and an instrument to fight pandemics

  2021cites this paper