Reengineering protein-phosphorylation switches

Phosphorylation circuits operate as logic gates that rapidly toggle a system between two stable states Toggle switches and oscillations in cellular networks have been of scientific interest since the late 1990s (1–4). Synthetic biologists have strived to build similar input-output responses by constructing DNA-RNA-protein circuits (1). Engineering genetic circuits has seen successes, including a synthetic circadian clock with oscillation periods of hours (5) and genetic bistable toggle switches operating on time scales of tens of minutes to hours (6). On page 75 of this issue, Mishra et al. (7) report the design of a faster regulatory network in yeast comprising synthetic protein phosphorylation circuits that act as logic gates. Furthermore, the authors identified similar network motifs across known endogenous signaling pathways in yeast.

• Publication year

  2021

• Venue

  Science

• Publication date

  2021-07-02

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1126/science.abj5028PMID 34210865PMCID PMC8327301
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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