Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Human Molecular Genetics

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/hmg/ddn044PMID 18270208PMCID PMC2902291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2007influential reference
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  2006influential reference
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  2002influential reference
• Neuronal nicotinic receptors: from structure to function.

  2001cited by this paper
• The human and financial costs of smoking.

  2000cited by this paper
• The genetic epidemiology of smoking.

  1999cited by this paper
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  1998cited by this paper
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  1995cited by this paper
• Actual causes of death in the United States.

  1993cited by this paper
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